Journal of Mushroom (한국버섯학회지)

The Korean Society of Mushroom Science (한국버섯학회)
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Effect of Paecilomyces tenuipes extract on angiogenesis in prostate cancer cells

눈꽃동충하초 추출물이 전립선 암 세포 내 혈관신생인자 발현에 미치는 영향

  • Choi, Young-Jin (Division of Food Bioscience, Konkuk University) ;
  • Fan, Meiqi (Division of Food Bioscience, Konkuk University) ;
  • Choi, Eun-Ju (Department of Physical Education, Daegu Catholic University) ;
  • Kim, Eun-kyung (Division of Food Bioscience, Konkuk University)
  • 최영진 (건국대학교 식품생명과학부) ;
  • 범미기 (건국대학교 식품생명과학부) ;
  • 최은주 (대구가톨릭대학교 체육교육과) ;
  • 김은경 (건국대학교 식품생명과학부)
  • Received : 2017.12.18
  • Accepted : 2017.12.22
  • Published : 2017.12.31
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Abstract

In this study, the inhibitory effect of Paecilomyces tenuipes extract on PSA and angiogenesis-related factor expression levels were investigated in human prostate cancer cells, LNCaP. P. tenuipes extract significantly inhibited PSA expression in a dose-dependent manner. We also investigated the inhibitory effect of P. tenuipes extract on the expression of angiogenesis-related genes including VEGF, MMP-2, MMP-9, TIMP-1, and TIMP-2. P. tenuipes extract significantly down-regulated the expression of MMP-2 and MMP-9 in a dose-dependent manner. On the contrary, P. tenuipes increased the expression of TIMP-1 and TIMP-2. Our findings indicate that P. tenuipes exhibits an inhibitory effect on angiogenesis in human prostate cancer cells.

본 연구에서는 눈꽃동충하초를 열수추출하여 항전립선암 효능을 조사하였다. 눈꽃동충하초 열수추출물은 PSA 발현을 저해하는 효능이 탁월하였으며, 또한 전립선암세포의 혈관신생인자 중 TIMP-1과 TIMP-2의 발현을 증가시킴과 동시에 MMP-2와 MMP-9의 발현을 감소시켜 혈관신생 작용을 억제하는 것으로 확인되었다. 이상의 결과는 이후 눈꽃동충하초를 이용한 항전립선암 연구에 대한 기초자료로가 될 것이며, 혈관신생억제와 관련된 이외의 경로에 대한 추가 연구가 필요할 것으로 사료된다.

Keywords

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