The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Case Series of Refractory Gastroesophageal Reflux Disease Treated with Lijin-tang-gamibang

이진탕가미방(二陳湯加味方)을 투여한 불응성 위식도역류질환의 증례군 연구

  • Ha, Na-yeon (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital) ;
  • Han, Ga-jin (Soram Korean Medicine Hospital) ;
  • Kim, Dae-jun (Dept. of Korean Internal Medicine, College of Korean Medicine, Daegu Haany University) ;
  • Ko, Seok-jae (Dept. of Korean Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Park, Jae-woo (Dept. of Korean Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Jin-sung (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital)
  • 하나연 (경희대학교한방병원 위장소화내과) ;
  • 한가진 (소람한방병원) ;
  • 김대준 (대구한의대학교 한의과대학 한방내과학) ;
  • 고석재 (경희대학교 한의과대학 비계내과학교실) ;
  • 박재우 (경희대학교 한의과대학 비계내과학교실) ;
  • 김진성 (경희대학교한방병원 위장소화내과)
  • Received : 2017.11.29
  • Accepted : 2018.01.05
  • Published : 2017.12.30
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Abstract

Objectives: The purpose of this study was to investigate the efficacy of Lijin-tang-gamibang on refractory gastroesophageal reflux disease (GERD). Methods: This before-and-after study compared the first medical examination and examination at the end of medical treatment. Twelve refractory GERD patients who visited the Department of Digestive Diseases of Kyung Hee University Korean Medicine Hospital from August 14th, 2017 to October 14th, 2017, were treated with Lijin-tang-gamibang for four consecutive weeks. The clinical characteristics of refractory GERD and the efficacy of herbal medical treatment was assessed by questionnaires, the Nepean Dyspepsia Index-Korean version (NDI-K), the Korean Gastrointestinal Symptom Rating Scale (KGSRS), the Numerical Rating Scale (NRS), the Korean version of the Perceived Stress Scale (KPSS-10), the Qi Stagnation Questionnaire (QSQ), the Spleen Qi Deficiency Questionnaire (SQDQ), and the Patient Global Impression of Change (PGIC). Prolonged effects were reported upon the follow-up telephone survey two weeks after treatment. Results: After treatment with the herbal medicine Lijin-tang-gamibang, the clinical characteristics of 12 refractory GERD patients were improved, especially in terms of the most common symptoms of acid regurgitation and heartburn. Each symptom score of NDI-K, KGSRS, NRS, SQDQ, and PGIC showed significant advances. Prolonged effects were reported in NDI-K, NRS and PGIC questionnaires two weeks after treatment. Conclusions: These results suggest that Lijin-tang-gamibang is an effective treatment for refractory GERD.

Keywords

References

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