Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Endophilin A2: A Potential Link to Adiposity and Beyond

  • Alfadda, Assim A. (Obesity Research Center, College of Medicine, King Saud University) ;
  • Sallam, Reem M. (Obesity Research Center, College of Medicine, King Saud University) ;
  • Gul, Rukhsana (Obesity Research Center, College of Medicine, King Saud University) ;
  • Hwang, Injae (Department of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University) ;
  • Ka, Sojeong (Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University)
  • Received : 2017.07.19
  • Accepted : 2017.09.20
  • Published : 2017.11.30
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Abstract

Adipose tissue plays a central role in regulating dynamic cross-talk between tissues and organs. A detailed description of molecules that are differentially expressed upon changes in adipose tissue mass is expected to increase our understanding of the molecular mechanisms that underlie obesity and related metabolic co-morbidities. Our previous studies suggest a possible link between endophilins (SH3Grb2 proteins) and changes in body weight. To explore this further, we sought to assess the distribution of endophilin A2 (EA2) in human adipose tissue and experimental animals. Human paired adipose tissue samples (subcutaneous and visceral) were collected from subjects undergoing elective abdominal surgery and abdominal liposuction. We observed elevated EA2 gene expression in the subcutaneous compared to that in the visceral human adipose tissue. EA2 gene expression negatively correlated with adiponectin and chemerin in visceral adipose tissue, and positively correlated with $TNF-{\alpha}$ in subcutaneous adipose tissue. EA2 gene expression was significantly downregulated during differentiation of preadipocytes in vitro. In conclusion, this study provides a description of EA2 distribution and emphasizes a need to study the roles of this protein during the progression of obesity.

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References

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