The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Antioxidant Activity and Anti-Adipogenic Effect of Ligularia stenocephala Extract

곤달비 추출물의 항산화 활성 및 지방세포 분화 억제 효과

  • Seo, Dongyeon (School of Food Biotechnology & Nutrition, Kyungsung University) ;
  • Cheon, Wonyoung (School of Food Biotechnology & Nutrition, Kyungsung University) ;
  • Kim, Younghwa (School of Food Biotechnology & Nutrition, Kyungsung University)
  • 서동연 (경성대학교 식품응용공학부) ;
  • 천원영 (경성대학교 식품응용공학부) ;
  • 김영화 (경성대학교 식품응용공학부)
  • Received : 2017.10.19
  • Accepted : 2017.11.12
  • Published : 2017.12.31
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Abstract

The purpose of this study was to evaluate the antioxidant and anti-adipogenic activities of Ligularia stenocephala (L. stenocephala) extract. The contents of the total polyphenol of the extract was 55.950 mg GAE/g residue. Antioxidant activities of L. stenocephala were evaluated by free radical scavenging ability and a reducing power test. 2,2'azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and ${\alpha}$-${\alpha}$-diphenyl-${\beta}$-picrylhydrazyl (DPPH) free radical scavenging activities of the extract were approximately 90% and 70%, respectively. Reducing power of the extract was 258.833 mg TE/g residue. The anti-adipogenic activity of L. stenocephala extract was examined in 3T3-L1 cells. During adipocyte differentiation, the 3T3-L1 cells were treated both with and without the extract. L. stenocephala extract suppressed the lipid accumulation in a concentration-dependent manner in the 3T3-L1 cells. The L. stenocephala extract inhibited the expression of peroxisome proliferator activated receptor ${\gamma}$ ($PPAR{\gamma}$) and adipocyte protein 2 (aP2) proteins, compared with control adipocytes. These results indicate that L. stenocephala could be regarded as a potential source natural antioxidant and an anti-obesity agent.

Keywords

References

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