Journal of the Korea Convergence Society (한국융합학회논문지)

Korea Convergence Society (한국융합학회)
권호 표지
DOI QR코드

DOI QR Code

Convergence study of oxidative stress from fraction of Xanthium strumarium L.

도꼬마리 추출물의 산화적 스트레스에 대한 융합연구

  • Received : 2017.10.20
  • Accepted : 2017.12.20
  • Published : 2017.12.28
Download PDF
⟨ Previous Next ⟩

Abstract

Xanthium strumarium L. is an annual plant belongs to the family Asteraceae which is is called a 'Cocklebur' that is used for medicinal purposes. Convergent phyto-activity of various extracts of Xanthium strumarium L. (Asteraceae) was examined. We estimated antioxidant activity from ground part and fruit extract of X. strumarium using 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH) and ABTS assay. The extract of X. strumarium was separated each fraction that of ethanol, petroleum ether, and ethyl acetate. It showed potent radical scavenging effect against the DPPH radical and ABTS. The study revealed that X. strumarium could be used as a potential source of natural antioxidant.

도꼬마리 (X. strumarium )는 국화과에 속하며, '창이자'라는 한약명으로 사용되는 다년생 식물이다. 열매부위와 지상부위의 추출물을 이용하여 융합 식물활성작용을 관찰하였다. 산화적 스트레스에 대항하는 실험법으로는 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH), ABTS assay를 사용하였다. 도꼬마리의 추출물은 단일분리가 아닌 ethanol, petroleum ether, 그리고 ethyl acetate로 추출하였다. 산화적 스트레스연구에 사용되는 radical scavenging 능력을 확인하기 위하여 DPPH radical and ABTS를 투여하였다. 본 연구에서 도꼬마리는 천연유래 항산화 효과를 보였다.

Keywords

References

  1. J. H. Park, Y .S. Min. "Antioxidant Activities of Xanthium strumarium Fruit and stem Extracts." The Journal of Applied Oriental Medicine, Vol. 10, No. 2, pp. 17-23, 2010.
  2. A. Sanchez-Lamar, J, Piloto-Ferrer. F. Degrassi. "Xanthium strumarium extract inhibits mammalian cell proliferation through mitotic spindle disruption mediated by xanthatin." J Ethnopharmacol, Vol. 194, pp. 781-788, 2016. https://doi.org/10.1016/j.jep.2016.11.006
  3. C. S. Yook. Clourred medicinal plants of Korea, Seoul Academy press pp. 305-310, 1990.
  4. K.W. Lee, S. J. Lee, H. K. Park, M. J. Kim, J. S. Jeong, E. K. Hong, C. K. Joo. "Antioxidant Activity of Xanthium Strumarium L. Extracted Fractions in Lens Epithelial Cells." Journal of The Korean Ophthalmological Society, Vol 42, No 1, pp. 152-159, 2001.
  5. NB. Sridlharamurthy, R. Yogananda, U. Srinivas. "In-vitro antioxidant and Antilipidemic Activites of Xanthium." Current Trends in Biotechnology & Pharmacy, Vol. 5, No. 3, pp. 1362-1371, 2011.
  6. D Jain, SB Shukla, S Verma "Lack of analgesic property in Xantium strumarium Linn. Fruit's butanolic extracts." Journal of Pharmaceutical Negative Results Vol. 3, No. 1, pp. 22-25, 2012. https://doi.org/10.4103/0976-9234.99643
  7. K. Apel, H. Hirt. "Reactive Oxygen Species: Metabolism, Oxidative Stress, and Signal Transduction." Annu. Rev. Plant Biol. Vol. 55, pp. 373-399, 2004. https://doi.org/10.1146/annurev.arplant.55.031903.141701
  8. M. Al Shahrani, S. Heales, I. Hargreaves, M Orford. "Oxidative Stress: Mechanistic Insights into Inherited Mitochondrial Disorders and Parkinson's Disease." Clin, Med., vol. 6, No. 11, p. 100. 2017. https://doi.org/10.3390/jcm6110100
  9. JT. Kumpulainen, JT. Salonen. "Natural Antioxidants and Anticarcinogenens in Nutrition, Health and Disease." The Royal Society of chemistry, UK, pp. 69-83. (1999).
  10. F. Pourmorad, SJ. Hosseinimehr, N. Shahabimajd. "Antioxidant activity, phenol and flavonoid contents of some selected Iranian medicinal plants." African Journal of Biotechnology, Vol. 5, No. 11, pp. 1142-1145, 2006.
  11. JM Kim, SH. Choi, OH. Lee. "Method validation and measurement uncertainty for the simultaneous determination of synthetic phenolic antioxidants in edible oils commonly consumed in Korea." Food Chem., Vol. 213, No. 15, pp. 19-25, 2016. https://doi.org/10.1016/j.foodchem.2016.06.053
  12. S. Robu, AC Aprotosoaie AC, A. Miron, O. Cioanca, "In vitro antioxidant activity of Ethanolic extracts from some Lavandula species cultivated in Romania." Farmacia, Vol. 60, No. 3, pp. 394-401, 2012.
  13. N. Gupta, S. Bhattacharya, RK Sharma, E. Narang. "In vitro Comparative Antioxidant Activity of Ethanolic Extracts of Glycosmis pentaphylla, Bauhinia variegata and Leucas aspera." Journal of Pharmaceutical Research, Vol. 10, No. 1, pp. 42-45. 2011.
  14. H.S. Kim, I. S. Lee, S. H. Yeo, L. S. Seong, T. S. Yu, "Isolization and characterization of antitumor agents from Xanthium strumarium L." Korean J. Biotechnol. Bioeng, Vol. 18, No. 4, pp. 324-328, 2003.
  15. S. M. Park, H. J. Jung, S. H. Han, S. H. Yeo, Y. W. Kim, H. G. Ahn, H. S. KimS, T. S. Yu. "Antifungal activity of extract from Xanthium strumarium L. against plant pathogenous fungi." Journal of Life Science, Vol. 15, No. 5, pp. 692-695, 2005. https://doi.org/10.5352/JLS.2005.15.5.692
  16. B. Hsu, L. M. Coupar, K. Ng. "Antioxidant activity of hot water extract from the fruit of the Doum palm, Hyphaene thebaica." Food Chem, Vol. 98, No. 2. pp. 317-328, 2006. https://doi.org/10.1016/j.foodchem.2005.05.077
  17. Y. M. Park, J. B. Jeong, J. H. Seo, J. H. Lim, H. J. Jeong, E. W. Seo. "Inhibitory Effect of Red Bean (Phaseolus angularis) Hot Water Extracts on Oxidative DNA and Cell Damage.", Korean J. Plant Res, Vol. 24, No. 2, pp. 130-138, 2011. https://doi.org/10.7732/kjpr.2011.24.2.130
  18. M. Nasir, S. Rauf, A. Hayat. "Biomimetic nitrogen doped titania nanoparticles as a colorimetric platform for hydrogen peroxide detection." J. Colloid Interface Sci. Vol 505, No 1, pp 1147-1157, 2017. https://doi.org/10.1016/j.jcis.2017.07.014
  19. R. Kah, H. Kappus. "Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E.", Z Lebensm Unters Forsch, Vol. 196, No. 4, pp. 329-338, 1993. https://doi.org/10.1007/BF01197931
  20. VK. Gupta, SK. Sharma. "Plants as natural antioxidants." Natural Product Radiance, Vol. 5, No. 4, pp. 326-334, 2006.
  21. HY. Hana, S. Shanb, X, Zhanga, "Down-regulation of prostate specific antigen in LNCaP cells by flavonoids from the pollen of Brassica napus L.", Phytomedicine, Vol. 14, pp. 338-343, 2007. https://doi.org/10.1016/j.phymed.2006.09.005
  22. I. Zila, A. Brozmanova, "Effects of Hypovolenia on Hypercapnic Ventilatory Response in Experimental Hyperthermia." J. Physiol. Pharmacol, Vol. 58, pp. 781-790, 2007.