Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics (대한후두음성언어의학회지)

The Korean Society of Laryngology, Phoniatrics and Logopedics. (대한후두음성언어의학회)
권호 표지

Effectiveness of Proton Pump Inhibitor in the Treatment of Contact Granuloma

접촉성 육아종에서 양성자 펌프 억제제의 치료 효과

  • Kim, Dong Hwan (Department of Otorhinolaryngology-Head and Neck Surgery, Hanyang University College of Medicine) ;
  • Kim, Keon Ho (Department of Otorhinolaryngology-Head and Neck Surgery, Hanyang University College of Medicine) ;
  • Jung, Seon Min (Department of Otorhinolaryngology-Head and Neck Surgery, Hanyang University College of Medicine) ;
  • Song, Chang Myeon (Department of Otorhinolaryngology-Head and Neck Surgery, Hanyang University College of Medicine) ;
  • Ji, Yong Bae (Department of Otorhinolaryngology-Head and Neck Surgery, Hanyang University College of Medicine) ;
  • Tae, Kyung (Department of Otorhinolaryngology-Head and Neck Surgery, Hanyang University College of Medicine)
  • 김동환 (한양대학교 의과대학 이비인후-두경부외과학교실) ;
  • 김건호 (한양대학교 의과대학 이비인후-두경부외과학교실) ;
  • 정선민 (한양대학교 의과대학 이비인후-두경부외과학교실) ;
  • 송창면 (한양대학교 의과대학 이비인후-두경부외과학교실) ;
  • 지용배 (한양대학교 의과대학 이비인후-두경부외과학교실) ;
  • 태경 (한양대학교 의과대학 이비인후-두경부외과학교실)
  • Received : 2017.10.31
  • Accepted : 2017.11.13
  • Published : 2017.12.30
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Abstract

Background and Objectives : Contact granuloma is granulation tissue that occurs mainly in the vocal process of arytenoid cartilage. Among several etiological factors, gastric acid reflux is known to be an important cause. The aim of this study was to evaluate clinical characteristics of contact granuloma and analyze the effectiveness of proton pump inhibitor in the treatment of contact granuloma. Materials and Methods : We retrospectively reviewed the medical records of 40 patients who were treated with proton pump inhibitor (PPI) for contact granuloma from January 2011 to December 2015. Reflux finding score (RFS), reflux symptom index (RSI) and size of granuloma were evaluated before and after treatment serially to assess the effectiveness of proton pump inhibitor. Results : Of 40 patients, 25 patients (62.5%) and 10 patients (25%) showed improvement and partial improvement of granuloma, respectively. Five patients showed no response. The mean times of partial improvement and improvement were $2.08{\pm}2.23$ months and $4.60{\pm}2.77$ months, respectively and mean duration of PPI treatment was $6.8{\pm}5.2$ months. Conclusion : Proton pump inhibitors is effective in the treatment of contact granuloma.

Keywords

References

  1. Hoffman HT, Overholt E, Karnell M, McCulloch TM. Vocal process granuloma. Head Neck 2001;23(12):1061-74. https://doi.org/10.1002/hed.10014
  2. Lee SW, Hong JH, Choi SH, Sun DI, Park YH, Lee BJ, et al. Comparison of Treatment Modalities for Contact Granuloma: A Nationwide Multicenter Study. Laryngoscope 2014;124:1187-91, https://doi.org/10.1002/lary.24470
  3. Ylitalo R, Lindestad PA. A retrospective study of contact granuloma. Laryngoscope 1999;109:433-6. https://doi.org/10.1097/00005537-199903000-00017
  4. Carroll TL, Gartner-Schmidt J, Statham MM, Rosen CA. Vocal process granuloma and glottal insufficiency: an overlooked etiology? Laryngoscope 2010;120:114-20. https://doi.org/10.1002/lary.21321
  5. Havas TE, Priestley J, Lowinger DS. A management strategy for vocal process granulomas. Laryngoscope 1999;109:301-6. https://doi.org/10.1097/00005537-199902000-00023
  6. Shin T, Watanabe H, Oda M, Umezaki T, Nahm I. Contact granulomas of the larynx. Eur Arch Otorhinolaryngol 1994;251:67-71.
  7. Belafsky PC1, Postma GN, Koufman JA. The validity and reliability of the reflux finding score (RFS). Laryngoscope 2001;111(8):1313-7. https://doi.org/10.1097/00005537-200108000-00001
  8. Emami AJ, Morrison M, Rammage L, Bosch D. Treatment of laryngeal contact ulcers and granulomas: a 12-year retrospective analysis. J Voice 1999;13:612-7. https://doi.org/10.1016/S0892-1997(99)80015-0
  9. Ylitalo R, Lindestad PA. Laryngeal Findings in Patients with Contact Granuloma: a Long-Term Follow-Up Study. Acta Otolaryngol 2000;120:655-9. https://doi.org/10.1080/000164800750000504
  10. Roh HJ, Goh EK, Chon KM, Wang SG. Topical inhalant steroid (budesonide, Pulmicort nasal) therapy in intubation granuloma. J Laryngol Otol 1999;113:427-32. https://doi.org/10.1017/S0022215100144147
  11. Yilmaz T, Suslu N, Atay G, Ozer S, Gunaydin RO, Bajin MD. Recurrent contact granuloma: experience with excision and botulinum toxin injection. JAMA Otolaryngol Head Neck Surg 2013;139:579-83. https://doi.org/10.1001/jamaoto.2013.3186
  12. Clyne SB, Halum SL, Koufman JA, Postma GN. Pulsed dye laser treatment of laryngeal granulomas. Ann Otol Rhinol Laryngol 2005;114:198-201. https://doi.org/10.1177/000348940511400305
  13. Mitchell G, Pearson CR, Henk JM, Rhys-Evans P. Excision and lowdose radiotherapy for refractory laryngeal granuloma. J Laryngol Otol 1998;112:491-3. https://doi.org/10.1017/S0022215100140873
  14. Hillel AT, Lin LM, Samlan R, Starmer H, Leahy K, Flint PW. Inhaled triamcinolone with proton pump inhibitor for treatment of vocal process granulomas: a series of 67 granulomas. Ann Otol Rhinol Laryngol 2010;119:325-30. https://doi.org/10.1177/000348941011900509
  15. Jin YJ, Lee SJ, Lee WY, Jeong WJ, Ahn SH. Prognostic factors for prediction of follow-up outcome of contact. granuloma. Eur Arch Otorhinolaryngol 2014;271:1981-5. https://doi.org/10.1007/s00405-014-2915-8
  16. Wang CP, Ko JY, Wang YH, Hu YL, Hsiao TY. Vocal process granuloma - A result of long-term observation in 53 patients. Oral Oncol 2009;45: 821-5. https://doi.org/10.1016/j.oraloncology.2009.01.008
  17. Lee JC, Wang SG, Management of Vocal Process Granuloma. Korean J Otolaryngol 2005;48:70-3.
  18. Shin T, Watanabe H, Oda M, Umezaki T, Nahm I. Contact granulomas of the larynx. Eur Arch Otorhinolaryngol 1994;251:67-71.