대한수의학회지 (Korean Journal of Veterinary Research)

  • 제57권4호
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  • Pages.249-252
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  • 2017
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  • 2466-1384(pISSN)
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  • 2466-1392(eISSN)
대한수의학회 (The Korean Society of Veterinary Science)
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Conservation of matrix protein genes in rabies viruses circulating in South Korea since 1999

  • Lee, Young-Ae (Viral Disease Research Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affair) ;
  • Kim, Ha-Hyun (Viral Disease Research Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affair) ;
  • Yang, Dong-Kun (Viral Disease Research Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affair) ;
  • Cho, In-Soo (Viral Disease Research Division, Animal and Plant Quarantine Agency, Ministry of Agriculture, Food and Rural Affair)
  • 투고 : 2017.09.15
  • 심사 : 2017.10.24
  • 발행 : 2017.12.31
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초록

Rabies virus (RABV) causes a neurological disease in warm-blooded animals that is nearly always fatal. In this study, we analyzed the matrix (M) genes in 10 Korean street RABV strains isolated from two Provinces during 2011-2013. The M genes in these 10 Korean strains were highly conserved during 1999-2013. Phylogenetic analysis revealed they were closely related to the M genes of RABVs isolated in northeastern China. Specific amino acid substitutions were identified in the KRVB1206, KRVF1301, and BV9901PJ strains. However, functional domains, including those involved in virus production and pathogenicity, were conserved in all 10 strains.

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참고문헌

  1. Ben Khalifa Y, Luco S, Besson B, Sonthonnax F, Archambaud M, Grimes JM, Larrous F, Bourhy H. The matrix protein of rabies virus binds to RelAp43 to modulate $NF-{\kappa}B$-dependent gene expression related to innate immunity. Sci Rep 2016, 6, 39420. https://doi.org/10.1038/srep39420
  2. Capone J, Ghosh HP. Association of the nucleocapsid protein N of vesicular stomatitis virus with phospholipid vesicles containing the matrix protein M. Can J Biochem Cell Biol 1984, 62, 1174-1180. https://doi.org/10.1139/o84-151
  3. Finke S, Conzelmann KK. Dissociation of rabies virus matrix protein functions in regulation of viral RNA synthesis and virus assembly. J Virol 2003, 77, 12074-12082. https://doi.org/10.1128/JVI.77.22.12074-12082.2003
  4. Finke S, Mueller-Waldeck R, Conzelmann KK. Rabies virus matrix protein regulates the balance of virus transcription and replication. J Gen Virol 2003, 84, 1613-1621. https://doi.org/10.1099/vir.0.19128-0
  5. Ge P, Tsao J, Schein S, Green TJ, Luo M, Zhou ZH. Cryo-EM model of the bullet-shaped vesicular stomatitis virus. Science 2010, 327, 689-693. https://doi.org/10.1126/science.1181766
  6. Gholami A, Kassis R, Real E, Delmas O, Guadagnini S, Larrous F, Obach D, Prevost MC, Jacob Y, Bourhy H. Mitochondrial dysfunction in lyssavirus-induced apoptosis. J Virol 2008, 82, 4774-4784. https://doi.org/10.1128/JVI.02651-07
  7. Irie T, Licata JM, McGettigan JP, Schnell MJ, Harty RN. Budding of PPxY-containing rhabdoviruses is not dependent on host proteins TGS101 and VPS4A. J Virol 2004, 78, 2657-2665. https://doi.org/10.1128/JVI.78.6.2657-2665.2004
  8. Kassis R, Larrous F, Estaquier J, Bourhy H. Lyssavirus matrix protein induces apoptosis by a TRAIL-dependent mechanism involving caspase-8 activation. J Virol 2004, 78, 6543-6555. https://doi.org/10.1128/JVI.78.12.6543-6555.2004
  9. Kim CH, Lee CG, Yoon HC, Nam HM, Park CK, Lee JC, Kang MI, Wee SH. Rabies, an emerging disease in Korea. J Vet Med B Infect Dis Vet Public Health 2006, 53, 111-115. https://doi.org/10.1111/j.1439-0450.2006.00928.x
  10. McGettigan JP, David F, Figueiredo MD, Minke J, Mebatsion T, Schnell MJ. Safety and serological response to a matrix gene-deleted rabies virus-based vaccine vector in dogs. Vaccine 2014, 32, 1716-1719. https://doi.org/10.1016/j.vaccine.2014.01.043
  11. Oem JK, Kim SH, Kim YH, Lee MH, Lee KK. Reemergence of rabies in the southern Han river region, Korea. J Wildl Dis 2014, 50, 681-688. https://doi.org/10.7589/2013-07-177
  12. World Health Organization (WHO). WHO expert committee on rabies. World Health Organ Tech Rep Ser 1992, 824, 1-84.
  13. Wu H, Wang L, Tao X, Li H, Rayner S, Liang G, Tang Q. Genetic diversity and molecular evolution of the rabies virus matrix protein gene in China. Infect Genet Evol 2013, 16, 248-253. https://doi.org/10.1016/j.meegid.2013.02.009
  14. Yang DK, Park YN, Hong GS, Kang HK, Oh YI, Cho SD, Song JY. Molecular characterization of Korean rabies virus isolates. J Vet Sci 2011, 12, 57-63. https://doi.org/10.4142/jvs.2011.12.1.57