BMB Reports

Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Gastrin-releasing peptide promotes the migration of vascular smooth muscle cells through upregulation of matrix metalloproteinase-2 and -9

  • Park, Hyun-Joo (Department of Oral Physiology, BK21 PLUS Project, School of Dentistry, Pusan National University) ;
  • Kim, Mi-Kyoung (Department of Oral Physiology, BK21 PLUS Project, School of Dentistry, Pusan National University) ;
  • Kim, Yeon (Department of Oral Physiology, BK21 PLUS Project, School of Dentistry, Pusan National University) ;
  • Bae, Sun Sik (Department of Pharmacology, Pusan National University School of Medicine, Pusan National University) ;
  • Kim, Hyung Joon (Department of Oral Physiology, BK21 PLUS Project, School of Dentistry, Pusan National University) ;
  • Bae, Soo-Kyung (Department of Dental Pharmacology, BK21 PLUS Project, School of Dentistry, Pusan National University) ;
  • Bae, Moon-Kyoung (Department of Oral Physiology, BK21 PLUS Project, School of Dentistry, Pusan National University)
  • Received : 2017.08.14
  • Accepted : 2017.10.11
  • Published : 2017.12.31
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Abstract

Gastrin-releasing peptide (GRP) has been reported to be implicated in the pathogenesis of inflammatory disorders. The migration and proliferation of vascular smooth muscle cells (VSMCs) are key components of vascular inflammation that leads to the development of atherosclerosis. The present study aimed to investigate the molecular effect of GRP on VSMC proliferation and migration. We report that GRP significantly enhanced the proliferation and migration of rat VSMCs. GRP increased mRNA and protein expression of matrix metalloproteinase-2 and -9 (MMP-2/9) in VSMCs. The induction of MMP-2/9 by GRP was regulated by the activation of the signal transducer and activator of transcription-3 (STAT3). In addition, STAT3-knockdown of VSMCs by siRNA or blockade of the GRP receptor inhibited GRP-induced migration of VSMCs. Taken together, our findings indicate that GRP promotes the migration of VSMCs through upregulation of MMP-2/9 via STAT3 activation.

Keywords

References

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