Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Lifespan-extending Effects of Allium hookeri Leaves in Caenorhabditis elegans

삼채 잎 추출물의 예쁜꼬마선충에 대한 수명연장 효과

  • Ki, Byeolhui (Department of Food Science and Technology, Chonbuk National University) ;
  • Lee, Eun Byeol (Functional Food & Nutrition Division, Department of Agro-food Resources, Rural Development Administration) ;
  • Kim, Jun Hyeong (College of Pharmacy, Woosuk University) ;
  • Yang, Jae Heon (Center for Healthcare Technology Development, Chonbuk National University) ;
  • Kim, Dae Keun (College of Pharmacy, Woosuk University) ;
  • Kim, Young-Soo (Department of Food Science and Technology, Chonbuk National University)
  • 기별희 (전북대학교 식품공학과) ;
  • 이은별 (농촌진흥청 국립농업과학원 기능성식품과) ;
  • 김준형 (우석대학교 약학대학) ;
  • 양재헌 (전북대학교 헬스케어기술개발사업단) ;
  • 김대근 (우석대학교 약학대학) ;
  • 김영수 (전북대학교 식품공학과)
  • Received : 2017.11.06
  • Accepted : 2017.12.06
  • Published : 2017.12.29
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Abstract

To evaluate the longevity property of Allium hookeri (Liliaceae) leaves, this study was performed. Ethanol extract of A. hookeri was successively partitioned as methylene chloride, ethyl acetate, n-butanol and $H_2O$ soluble fractions, and lifespan-extending effects of the fractions were checked using Caenorhabditis elegans model system. The most active ethyl acetate-soluble fraction elevated heat stress tolerance, and increased expression of stress resistance protein. Further studies were performed to investigate several aging-related factors such as reproduction, food intake, growth and movement of C. elegans. The results revealed that there were no significant changes in aging-related factors including reproduction and food intake, however, ethyl acetate-soluble fraction treatment led to up-regulation of locomotory ability and growth of aged worms, suggesting ethyl acetate-soluble fraction affected healthspan as well as lifespan of nematode.

Keywords

References

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