Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Steroidal saponins from Dioscorea nipponica Rhizomes and Their Biological Activity

부채마의 스테로이드 사포닌 및 생리활성

  • Park, Kyoung Jin (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Suh, Won Se (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Cha, Joon Min (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Park, Jong Eel (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Woo, Kyeong Wan (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University) ;
  • Kim, Sun Yeo (College of Pharmacy, Gachon University) ;
  • Lee, Kang Ro (Natural Product Laboratory, School of Pharmacy, Sungkyunkwan University)
  • 박경진 (성균관대학교 약학대학 천연물약품화학연구실) ;
  • 서원세 (성균관대학교 약학대학 천연물약품화학연구실) ;
  • 차준민 (성균관대학교 약학대학 천연물약품화학연구실) ;
  • 박종일 (성균관대학교 약학대학 천연물약품화학연구실) ;
  • 우경완 (성균관대학교 약학대학 천연물약품화학연구실) ;
  • 김선여 (가천대학교 약학대학) ;
  • 이강노 (성균관대학교 약학대학 천연물약품화학연구실)
  • Received : 2017.09.15
  • Accepted : 2017.12.01
  • Published : 2017.12.29
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Abstract

As part of the search for bioactive constituents of Korean medicinal plants, twelve steroids (1-12) were isolated from the rhizomes of Dioscorea nipponica. The isolated compounds were identified as diosgenin ($3{\beta}$, 25R)-spirost-5-en-3-ol (1), 25(R)-dracaenoside E (2), dioscin (3), gracillin (4), prosapogenin B (5), 25(R)-dracaenoside G (6), diosgenin 3-O-${\beta}$-D-glucopyranosyl($1{\rightarrow}3$)-${\beta}$-D-glucopyranoside (7), ophipogonin C′ (8), 7-oxodioscin (9), protodioscin (10), hypoglaucin F (11), and protoneogracillin (12). Their structures were characterized by spectroscopic data and identified by comparing these data with those in the literatures. All the isolates (1-12) were evaluated for their neuroprotective effects through induction of nerve growth factor in C6 glioma cells and effects on nitric oxide (NO) production in murine microglia cell line BV-2. Compounds 7 and 12 were found to induce upregulation of NGF secretion without causing significant cell toxicity and compound 4 exhibited potent anti-neuroinflammatory activity.

Keywords

References

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