Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Phenolic Compounds from the Leaves of Homonoia riparia and their Inhibitory Effects on Advanced Glycation End Product Formation

  • Lee, Ik-Soo (KM Convergence Research Division, Korea Institute of Oriental Medicine) ;
  • Jung, Seung-Hyun (Division of Marine-Bio Research, National Marine Biodiversity Institute of Korea) ;
  • Kim, Chan-Sik (KM Convergence Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Jin Sook (KM Convergence Research Division, Korea Institute of Oriental Medicine)
  • Received : 2017.08.21
  • Accepted : 2017.09.26
  • Published : 2017.12.29
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Abstract

In a search for novel treatments for diabetic complications from natural resources, we found that the ethyl acetate-soluble fraction from the 80% ethanol extract of the leaves of Homonoia riparia has a considerable inhibitory effect on advanced glycation end product (AGE) formation. Bioassay-guided isolation of this fraction resulted in identification of 15 phenolic compounds (1 - 15). These compounds were evaluated in vitro for inhibitory activity against the formation of AGE. The majority of tested compounds, excluding ethyl gallate (15), markedly inhibited AGE formation, with $IC_{50}$ values of $2.2-89.9{\mu}M$, compared with that of the positive control, aminoguanidine ($IC_{50}=962.3{\mu}M$). In addition, the effects of active isolates on the dilation of hyaloid-retinal vessels induced by high glucose (HG) in larval zebrafish was investigated; (-)-epigallocatechin-3-O-gallate (6), corilagin (7), and desmanthine-2 (11) significantly decreased HG-induced dilation of hyaloid-retinal vessels compared with the HG-treated control group.

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