Journal of Marine Bioscience and Biotechnology (한국해양바이오학회지)

The Korean Society for Marine Biotechnology (한국해양바이오학회)
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Streptomyces sp. DG-2 with Anti-MRSA (Methicillin Resistant Staphylococcus aureus) Activity

항 MRSA (Methicillin Resistant Staphylococcus aureus) 활성을 나타내는 Streptomyces sp. DG-2

  • Jeong, Seong-Yun (Department of Biomedical Science, Daegu Catholic University)
  • 정성윤 (대구가톨릭대학교 의생명과학과)
  • Received : 2017.12.07
  • Accepted : 2017.12.28
  • Published : 2017.12.31
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Abstract

We isolated marine bacterium, isolate DG-2 which produces the antibiotics against MRSA (methicillin-resistant Staphylococcus aureus). This isolate DG-2 was examined by its morphological, biochemical properties, and 16S rRNA sequencing analysis. And then, isolate DG-2 was identified to the genus Streptomyces. Therefore, this isolate was designated as Streptomyces sp. DG-2. Streptomyces sp. DG-2 grew relatively well at $25^{\circ}C$, pH 7.0, and NaCl 1.0%. For the pre-purification of the bioactive compounds, DG-2 was fermented in 30 L PPES-II medium, and the culture filtrates of DG-2 was extracted by ethyl acetate. The ethyl acetate extract of DG-2 showed the significant anti-MRSA and antibacterial activities.

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