Journal of Korean Biological Nursing Science

Korean society of Biological Nursing Science (한국기초간호학회)
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Effect of Environmental Factors on Depressive-like Behavior and Memory Function in Adolescent Rats

  • Song, Min Kyung (Department of Nursing, Graduate School, Kyung Hee University) ;
  • Lee, Jae-Min (Department of Physiology, College of Medicine, Kyung Hee University) ;
  • Kim, Yoon Ju (Department of Nursing, Graduate School, Kyung Hee University) ;
  • Lee, Joo Hee (Department of Nursing, Graduate School, Kyung Hee University) ;
  • Kim, Youn-Jung (College of Nursing Science, Kyung Hee University.East-West Nursing Research Institute)
  • Received : 2017.11.06
  • Accepted : 2017.11.25
  • Published : 2017.11.30
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Abstract

Purpose: The aim of this study was to identify the effects of environmental factors on depressive-like behavior and memory function during adolescence. We performed behavior tests in adolescent rats exposed to environmental enrichment, handling, and social deprivation for eight weeks. Methods: Wistar rats were randomly assigned to control, environmental enrichment, handling, and social deprivation groups at the age of four weeks. Results: In the forced swim test, the immobility time in the environmental enrichment group was decreased than that in the control group (p=.038), while the immobility time in the social deprivation group was increased than that in the control group (p=.035), the environmental enrichment group (p<.001), and the handling group (p=.001). In the Morris water maze test, the social deprivation group had an increased latency time than the control group (p=.013) and the environmental enrichment group (p=.001). In the passive avoidance test, the environmental enrichment group had an increased latency time than the control group (p=.005). However, the social deprivation group had reduced latency time than the socially housed groups (control: p=.030; environmental enrichment: p<.001; handling: p<.001). Conclusion: These findings suggest that environmental factors play an important role in emotion and memory function during adolescence.

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References

  1. Tamnes CK, Ostby Y, Fjell AM, Westlye LT, Due-Tonnessen P, Walhovd KB. Brain maturation in adolescence and young adulthood: regional age-related changes in cortical thickness and white matter volume and microstructure. Cerebral Cortex. 2010;20(3):534-548. https://doi.org/10.1093/cercor/bhp118
  2. Paus T. Mapping brain maturation and cognitive development during adolescence. Trends in Cognitive Sciences. 2005;9(2):60-68. https://doi.org/10.1016/j.tics.2004.12.008
  3. Steinberg L, Morris AS. Adolescent development. Annual Review of Psychology. 2001;52:83-110. https://doi.org/10.1146/annurev.psych.52.1.83
  4. Spear LP. The adolescent brain and age-related behavioral manifestations. Neuroscience and Biobehavioral Reviews. 2000;24(4):417-463. https://doi.org/10.1016/S0149-7634(00)00014-2
  5. Pechtel P, Pizzagalli DA. Effects of early life stress on cognitive and affective function: an integrated review of human literature. Psychopharmacology. 2011;214(1):55-70. https://doi.org/10.1007/s00213-010-2009-2
  6. La Greca AM, Prinstein MJ, Fetter MD. Adolescent peer crowd affiliation: linkages with health-risk behaviors and close friendships. Journal of Pediatric Psychology. 2001;26(3):131-143. https://doi.org/10.1093/jpepsy/26.3.131
  7. Rosenzweig MR, Bennett EL, Hebert M, Morimoto H. Social grouping cannot account for cerebral effects of enriched environments. Brain Research. 1978; 153(3):563-576. https://doi.org/10.1016/0006-8993(78)90340-2
  8. van Praag H, Kempermann G, Gage FH. Neural consequences of environmental enrichment. Nature Reviews Neuroscience. 2000;1(3):191-198. https://doi.org/10.1038/35044558
  9. Galani R, Berthel MC, Lazarus C, Majchrzak M, Barbelivien A, Kelche C, et al. The behavioral effects of enriched housing are not altered by serotonin depletion but enrichment alters hippocampal neurochemistry. Neurobiology of Learning and Memory. 2007;88(1):1-10. https://doi.org/10.1016/j.nlm.2007.03.009
  10. Brenes JC, Rodriguez O, Fornaguera J. Differential effect of environment enrichment and social isolation on depressive-like behavior, spontaneous activity and serotonin and norepinephrine concentration in prefrontal cortex and ventral striatum. Pharmacology, Biochemistry, and Behavior. 2008;89(1):85-93. https://doi.org/10.1016/j.pbb.2007.11.004
  11. Leggio MG, Mandolesi L, Federico F, Spirito F, Ricci B, Gelfo F, et al. Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat. Behavioural Brain Research. 2005;163(1):78-90. https://doi.org/10.1016/j.bbr.2005.04.009
  12. Jin X, Li T, Zhang L, Ma J, Yu L, Li C, et al. Environmental enrichment improves spatial learning and memory in vascular dementia rats with activation of Wnt/beta-catenin signal pathway. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2017;23:207-215. https://doi.org/10.12659/MSM.902728
  13. Cloutier S, Panksepp J, Newberry RC. Playful handling by caretakers reduces fear of humans in the laboratory rat. Applied Animal Behaviour Science. 2012;140(3-4):161-171. https://doi.org/10.1016/j.applanim.2012.06.001
  14. Cloutier S, Baker C, Wahl K, Panksepp J, Newberry RC. Playful handling as social enrichment for individually- and group-housed laboratory rats. Applied Animal Behaviour Science. 2013;143(2-4):85-95. https://doi.org/10.1016/j.applanim.2012.10.006
  15. Sciolino NR, Bortolato M, Eisenstein SA, Fu J, Oveisi F, Hohmann AG, et al. Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats. Neuroscience. 2010;168(2):371-386. https://doi.org/10.1016/j.neuroscience.2010.04.007
  16. Costa R, Tamascia ML, Nogueira MD, Casarini DE, Marcondes FK. Handling of adolescent rats improves learning and memory and decreases anxiety. Journal of the American Association for Laboratory Animal Science. 2012;51(5): 548-553.
  17. Pritchard LM, Van Kempen TA, Zimmerberg B. Behavioral effects of repeated handling differ in rats reared in social isolation and environmental enrichment. Neuroscience Letters. 2013;536:47-51. https://doi.org/10.1016/j.neulet.2012.12.048
  18. Pascual R, Zamora-Leon P, Catalan-Ahumada M, Valero-Cabre A. Early social isolation decreases the expression of calbindin D-28k and dendritic branching in the medial prefrontal cortex of the rat. The International Journal of Neuroscience. 2007;117(4):465-476. https://doi.org/10.1080/00207450600773459
  19. Lapiz MD, Fulford A, Muchimapura S, Mason R, Parker T, Marsden CA. Influence of postweaning social isolation in the rat on brain development, conditioned behavior, and neurotransmission. Neuroscience and Behavioral Physiology. 2003;33(1):13-29. https://doi.org/10.1023/A:1021171129766
  20. Toth M, Mikics E, Tulogdi A, Aliczki M, Haller J. Post-weaning social isolation induces abnormal forms of aggression in conjunction with increased glucocorticoid and autonomic stress responses. Hormones and Behavior. 2011;60(1):28-36. https://doi.org/10.1016/j.yhbeh.2011.02.003
  21. Kokare DM, Dandekar MP, Singru PS, Gupta GL, Subhedar NK. Involvement of alpha-MSH in the social isolation induced anxiety- and depression-like behaviors in rat. Neuropharmacology. 2010;58(7):1009-1018. https://doi.org/10.1016/j.neuropharm.2010.01.006
  22. Quan MN, Tian YT, Xu KH, Zhang T, Yang Z. Post weaning social isolation influences spatial cognition, prefrontal cortical synaptic plasticity and hippocampal potassium ion channels in Wistar rats. Neuroscience. 2010;169(1):214-222. https://doi.org/10.1016/j.neuroscience.2010.04.048
  23. Sengupta P. The laboratory rat: relating its age with human's. International Journal of Preventive Medicine. 2013;4(6):624-630.
  24. Charan J, Kantharia ND. How to calculate sample size in animal studies? Journal of Pharmacology & Pharmacotherapeutics. 2013;4(4):303-306. https://doi.org/10.4103/0976-500X.119726
  25. Porsolt RD, Bertin A, Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Archives Internationales de Pharmacodynamie et de Therapie. 1977;229(2):327-336.
  26. Bogdanova OV, Kanekar S, D'Anci KE, Renshaw PF. Factors influencing behavior in the forced swim test. Physiology & Behavior. 2013;118:227-239. https://doi.org/10.1016/j.physbeh.2013.05.012
  27. Morris R. Developments of a water-maze procedure for studying spatial learning in the rat. Journal of Neuroscience Methods. 1984;11(1):47-60. https://doi.org/10.1016/0165-0270(84)90007-4
  28. Vorhees CV, Williams MT. Morris water maze: Procedures for assessing spatial and related forms of learning and memory. Nature Protocols. 2006;1(2):848-858. https://doi.org/10.1038/nprot.2006.116
  29. Dietrich H, Jenck F. Intact learning and memory in rats following treatment with the dual orexin receptor antagonist almorexant. Psychopharmacology. 2010;212(2):145-154. https://doi.org/10.1007/s00213-010-1933-5
  30. Russell WMS, Burch RL. The principles of humane experimental technique. Special edition. London: Methuen; 1959. p.238.
  31. Ghasemi M, Dehpour AR. Ethical considerations in animal studies. Journal of Medical Ethics and History of Medicine. 2009;2:12.
  32. Chappell AM, Carter E, McCool BA, Weiner JL. Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male Long Evans rats. Alcoholism, Clinical and Experimental Research. 2013;37(s1):E394-E403. https://doi.org/10.1111/j.1530-0277.2012.01926.x
  33. Hellemans KG, Benge LC, Olmstead MC. Adolescent enrichment partially reverses the social isolation syndrome. Developmental Brain Research. 2004; 150(2):103-115. https://doi.org/10.1016/j.devbrainres.2004.03.003
  34. Barha CK, Brummelte S, Lieblich SE, Galea LA. Chronic restraint stress in adolescence differentially influences hypothalamic-pituitary-adrenal axis function and adult hippocampal neurogenesis in male and female rats. Hippocampus. 2011;21(11):1216-1227. https://doi.org/10.1002/hipo.20829