대한치과의사협회지 (The Journal of the Korean dental association)

  • 제54권5호
  • /
  • Pages.356-364
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  • 2016
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  • 0376-4672(pISSN)
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  • 2713-7961(eISSN)
대한치과의사협회 (The Korean Dental Association)
권호 표지

제 2형 당뇨 환자의 근관 감염에서 나타난 병원균과 그 항생제 감수성

Pathogens and Their Antimicrobial Susceptibilities of Endodontic Infection in Type II Diabetes Mellitus Patients

  • 조주연 (계명대학교 의과대학 동산의료원 치과) ;
  • 김성교 (경북대학교 치과대학병원 치과보존과)
  • Cho, Ju-Yeon (Department of Dentistry, Keimyeong University Dongsan Medical Center) ;
  • Kim, Sung-Kyo (Department of Conservative Dentistry, Kyngpook National University Hospital)
  • 투고 : 2015.10.30
  • 심사 : 2016.01.25
  • 발행 : 2016.05.01
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초록

Aim: The purpose of this study was to identify dominant pathogens and their antimicrobial susceptibilities of endodontic infection in type II diabetes mellitus (DM) patients to determine effective empirical antibiotics. Methodology: Pathogens from endodontic infection in six patients with DM and in six patients without DM were cultured, identified and their antimicrobial susceptibility was tested using Vitek2 systems ($bioM{\acute{e}}rieux$, Marcy l' Etoile, France). The results were analyzed using Chi-square test and Fisher's exact test at P< 0.05 level. Results: Pathogens of opportunistic infection were dominant in DM patients (P=0.015). However, there was no significant difference of antimicrobial susceptibility between DM and non-DM patients. Relatively high percent (27%) of pathogens showed resistance to penicillin. Conclusions: More cautions should be paid to DM patients because they are prone to opportunistic infection. Penicillin is not effective in the control of endodontic infection.

키워드

과제정보

연구 과제 주관 기관 : 계명대학교

참고문헌

  1. Manfredi M, McCullough MJ, Vescovi P, et al. Update on diabetes mellitus and related oral diseases. Oral Dis 2004;10(4):187-200. https://doi.org/10.1111/j.1601-0825.2004.01019.x
  2. Fouad AF. Diabetes mellitus as a modulating factor of endodontic infections. J Dent Educ 2003;67(4):459-467.
  3. Katz J. Elevated blood glucose levels in patients with severe periodontal disease. J Clin Periodontol 2001;28(7):710-712. https://doi.org/10.1034/j.1600-051x.2001.028007710.x
  4. Marotta PS, Fontes TV, Armada L, et al. Type 2 diabetes mellitus and the prevalence of apical periodontitis and endodontic treatment in an adult Brazilian population. J Endod 2012;38(3):297-300. https://doi.org/10.1016/j.joen.2011.11.001
  5. Lopez-Lopez J, Jane-Salas E, Estrugo-Devesa A, et al. Periapical and endodontic status of type 2 diabetic patients in Catalonia, Spain: a crosssectional study. J Endod 2011;37(5):598-601. https://doi.org/10.1016/j.joen.2011.01.002
  6. Bender IB, Bender AB. Diabetes mellitus and the dental pulp. J Endod 2003;29(6):383-389. https://doi.org/10.1097/00004770-200306000-00001
  7. Lima SM, Grisi DC, Kogawa EM, et al. Diabetes mellitus and inflammatory pulpal and periapical disease: a review. Int Endod J 2013;46(8):700-709. https://doi.org/10.1111/iej.12072
  8. Fouad AF, Kum KY, Clawson ML, et al. Molecular characterization of the presence of Eubacterium spp and Streptococcus spp in endodontic infections. Oral Microbiol Immunol 2003;18(4):249-255. https://doi.org/10.1034/j.1399-302X.2003.00077.x
  9. Fouad AF, Barry J, Caimano M, et al. PCR-based identification of bacteria associated with endodontic infections. J Clin Microbiol 2002;40(9):3223-3231. https://doi.org/10.1128/JCM.40.9.3223-3231.2002
  10. Vigil GV, Wayman BE, Dazey SE, et al. Identification and antibiotic sensitivity of bacteria isolated from periapical lesions. J Endod 1997;23(2):110-114. https://doi.org/10.1016/S0099-2399(97)80256-7
  11. Gomes BP, Jacinto RC, Montagner F, et al. Analysis of the antimicrobial susceptibility of anaerobic bacteria isolated from endodontic infections in Brazil during a period of nine years. J Endod 2011;37(8):1058-1062. https://doi.org/10.1016/j.joen.2011.05.015
  12. Ranta H, Haapasalo M, Ranta K, et al. Bacteriology of odontogenic apical periodontitis and effect of penicillin treatment. Scand J Infect Dis 1988;20(2):187-192. https://doi.org/10.3109/00365548809032436
  13. Baker PJ, Evans RT, Slots J, Genco RJ. Antibiotic susceptibility of anaerobic bacteria from the human oral cavity. J Dent Res 1985;64(10):1233-1244. https://doi.org/10.1177/00220345850640101201
  14. Lewis MA, MacFarlane TW, McGowan DA. Antibiotic susceptibilities of bacteria isolated from acute dentoalveolar abscesses. J Antimicrob Chemother 1989;23(1):69-77. https://doi.org/10.1093/jac/23.1.69
  15. Brook I, Frazier EH, Gher ME. Aerobic and anaerobic microbiology of periapical abscess. Oral Microbiol Immunol 1991;6(2):123-125. https://doi.org/10.1111/j.1399-302X.1991.tb00464.x
  16. Baumgartner JC, Xia T. Antibiotic susceptibility of bacteria associated with endodontic abscesses. J Endod 2003;29(1):44-47. https://doi.org/10.1097/00004770-200301000-00012
  17. Pereira CA, Toledo BC, Santos CT, et al. Opportunistic microorganisms in individuals with lesions of denture stomatitis. Diagn Microbiol Infect Dis 2013;76(4):419-424. https://doi.org/10.1016/j.diagmicrobio.2013.05.001
  18. Loberto JCS, Martins CAP, Santos SSF, et al. Staphylococcus spp. in the oral cavity and periodontal pockets of chronic periodontitis patients. Braz J Microbiol 2006;20:202-206.
  19. Casey AL, Lambert PA, Elliott TSJ. Staphylococci. Int J Antimicrob Agents 2007;29(SUPPL. 3):S23-S32.
  20. Lin GY, Yang FC, Lee JT, Wang CW. Streptococcus anginosus, tooth extraction and brain abscess. QJM 2013.
  21. Ivic I, Karanovi? J, Pavicic-Ivelja M. Sepsis with multiple abscesses caused by staphylococcus warneri: a case report. Central European Journal of Medicine 2013;8(1):45-47.
  22. Fowell C, Igbokwe B, MacBean A. The clinical relevance of microbiology specimens in orofacial abscesses of dental origin. Ann R Coll Surg Engl 2012;94(7):490-492. https://doi.org/10.1308/003588412X13373405385539
  23. Skucaite N, Peciuliene V, Vitkauskiene A, Machiulskiene V. Susceptibility of endodontic pathogens to antibiotics in patients with symptomatic apical periodontitis. J Endod 2010;36(10):1611-1616. https://doi.org/10.1016/j.joen.2010.04.009
  24. Lewis MA, Parkhurst CL, Douglas CW, et al. Prevalence of penicillin resistant bacteria in acute suppurative oral infection. J Antimicrob Chemother 1995;35(6):785-791. https://doi.org/10.1093/jac/35.6.785
  25. Sandor GK, Low DE, Judd PL, Davidson RJ. Antimicrobial treatment options in the management of odontogenic infections. J Can Dent Assoc 1998;64(7):508-514.
  26. Kuriyama T, Williams DW, Yanagisawa M, et al. Antimicrobial susceptibility of 800 anaerobic isolates from patients with dentoalveolar infection to 13 oral antibiotics. Oral Microbiol Immunol 2007;22(4):285-288. https://doi.org/10.1111/j.1399-302X.2007.00365.x
  27. Poeschl PW, Crepaz V, Russmueller G, et al. Endodontic pathogens causing deep neck space infections: clinical impact of different sampling techniques and antibiotic susceptibility. J Endod 2011;37(9):1201-1205. https://doi.org/10.1016/j.joen.2011.05.029
  28. Khemaleelakul S, Baumgartner JC, Pruksakorn S. Identification of bacteria in acute endodontic infections and their antimicrobial susceptibility. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;94(6):746-755. https://doi.org/10.1067/moe.2002.129535
  29. Ellison SJ. The role of phenoxymethylpenicillin, amoxicillin, metronidazole and clindamycin in the management of acute dentoalveolar abscesses--a review. Br Dent J 2009;206(7):357-362. https://doi.org/10.1038/sj.bdj.2009.257
  30. Siqueira JF, Jr., Rocas IN. Distinctive features of the microbiota associated with different forms of apical periodontitis. J Oral Microbiol 2009;1.
  31. Siqueira JF, Jr. Microbial causes of endodontic flare-ups. Int Endod J 2003;36(7):453-463. https://doi.org/10.1046/j.1365-2591.2003.00671.x