Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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Effects of Benzyltrialkylammonium Type Cationic Surfactants on the Preparation and Properties of Liposome

벤질트리알킬암모늄계 양이온성 계면활성제가 리포좀 제조와 특성에 미치는 영향

  • Jung, Yeonseok (Department of Engineering Chemistry, Chungbuk National University) ;
  • Jeong, Noh-Hee (Department of Engineering Chemistry, Chungbuk National University)
  • 정연석 (충북대학교 공과대학 공업화학과) ;
  • 정노희 (충북대학교 공과대학 공업화학과)
  • Received : 2016.07.19
  • Accepted : 2016.08.30
  • Published : 2016.09.30
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Abstract

In this study, benzyltrialkylammonium chlorides with different alkyl chain length were synthesized and applied to liposome. Prepared cationic surfactant embedded liposomes were measured particle size, zetapotential, release property and antibacterial activity. The average particle size of liposomes was 120~140 nm. As alkyl chain length was increased, the liposome size was increased. Zetapotential for the solution of liposomes added cationic surfactants were in the range of +80~90 mV. In release test, collagen release rate could be controlled by alkyl chain length. liposome embedded long alkyl chain surfactant had enhanced sustained release property. Entrapment efficiency of hydrophilic collagen were 25.9~27.5%.

본 연구에서는 알킬체인의 길이가 서로 다른 benzyltrialkylammonium chloride계 화합물을 합성하여 리포좀 제조에 응용하였다. 제조된 리포좀의 평균 입도분포, 제타전위, 방출거동 및 항균성을 조사하였으며, 사슬 길이에 따른 특성을 비교하였다. 리포좀의 평균 입도는 120~140 nm의 크기분포를 가졌으며 소수성 사슬의 길이가 증가할수록 큰 입자크기를 가졌다. 리포좀 용액의 제타전위는 양이온성 계면활성제인 benzyltrialkylammonium chloride를 첨가함에 따라 +80~90 mV의 값을 가지며 향상된 분산 안정성을 보였다. 방출거동에서는 사슬 길이에 따라 방출 속도를 조절할 수 있었으며 긴 사슬의 계면활성제를 첨가한 리포좀은 증가된 서방형 방출특성을 보였다. 또한, 리포좀의 포집효율은 25.9~27.5% 이었다.

Keywords

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