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Retrospective study on factors affecting the prognosis in oral cancer patients who underwent surgical treatment only

  • Kim, Byeong-Guk (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Kim, Jun-Hwa (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Kim, Myung-In (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Han, Jeong Joon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Jung, Seunggon (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Kook, Min-Suk (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Park, Hong-Ju (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Ryu, Sun-Youl (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University) ;
  • Oh, Hee-Kyun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Dental Science Research Institute, Chonnam National University)
  • Received : 2015.11.03
  • Accepted : 2015.12.01
  • Published : 2016.12.31

Abstract

Background: This study was performed to evaluate their 5-year survival rates and identify the factors affecting the prognosis of oral cancer patients who had undergone surgical treatment only. Methods: Among 130 patients who were diagnosed with malignant tumor of oral, maxillofacial, and surgical treated in the Department of Oral and Maxillofacial Surgery at Chonnam National University Hospital within a period from January 2000 to December 2010, for 11 years, 84 patients were investigated who were followed up for more than 5 years after radical surgery; oral cancer is primary and received only surgical treatment. The survival rate according to gender, age, type and site of cancer, TNM stage, cervical lymph node metastasis and its stage, recurrence or metastasis, time of recurrence and metastasis, and differentiation were investigated and analyzed. Results: Overall, 5-year survival rate in patients who received only surgical treatment was 81.2 %, and disease-specific 5-year survival rate was 83.1 %. The disease-specific 5-year survival rate based on TNM stage, metastasis of cervical lymph node, N stage, and presence of recurrence/metastasis was a significant difference (p < 0.05). The disease-specific 5-year survival rate based on sex, age, type of tumor, primary site, and differentiation was not a significant difference (p > 0.05). Conclusions: These results suggest that good survival rate can be obtained with surgical treatment only, and stage of oral cancer, cervical lymph node metastasis and stage, recurrence or metastasis, time of recurrence, and metastasis have a significant effect on survival rate in oral cancer patients.

Keywords

References

  1. Chen AY, Myers JN (2000) Cancer of oral cavity. Curr Probl Surg 37(10):633-731 https://doi.org/10.1016/S0011-3840(00)80018-0
  2. Miloro M, Ghali GE, Larsen PE, Waite PD (eds) (2012) Peterson's principles of oral and maxillofacial surgery, 3rd edn. McGraw-Hill, Shelton, p 696
  3. Omura K (2014) Current status of oral cancer treatment strategies: surgical treatments for oral squamous cell carcinoma. Int J Clin Oncol 19(3):423-30 https://doi.org/10.1007/s10147-014-0689-z
  4. Lim YC, Choi EC (2008) Surgery alone for squamous cell carcinoma of the oral cavity: survival rates, recurrence patterns, and salvage treatment. Acta Otolaryngol 128:1132-1137 https://doi.org/10.1080/00016480801901691
  5. Wolfensberger M, Zbaeren P, Dulguerov P, Muller W, Arnoux A, Schmid S (2001) Surgical treatment of early oral carcinoma-results of a prospective controlled multicenter study. Head Neck 23:525e-30 https://doi.org/10.1002/hed.1073
  6. Liu CH, Chen HJ, Wang PC, Chen HS, Chang YL (2013) Patterns of recurrence and second primary tumors in oral squamous cell carcinoma treated with surgery alone. Kaohsiung J Med Sci 29:554-559 https://doi.org/10.1016/j.kjms.2013.03.001
  7. Massano J, Regateiro FS, Janua'rio G, Ferreira A (2006) Oral squamous cell carcinoma: review of prognostic and predictive factors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:67-76 https://doi.org/10.1016/j.tripleo.2005.07.038
  8. Rajapakshe RM, Pallegama RW, Jayasooriya PR, Siriwardena BS, Attygalla AM, Hewapathirana S et al (2015) A retrospective analysis to determine factors contributing to the survival of patients with oral squamous cell carcinoma. Cancer Epidemiol 39(3):360-366 https://doi.org/10.1016/j.canep.2015.02.011
  9. Magge KT, Myers EN, Johnson JT (2003) Radiation following surgery for oral cancer: impact on local control. Laryngoscope 113(6):933-935 https://doi.org/10.1097/00005537-200306000-00003
  10. Edge S, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A (eds) (2010) AJCC cancer staging manual, 7th edn. Springer, Chicago, pp 29-40
  11. Amdur RJ, Parsons JT, Mendenhall WM, Million RR, Stringer SP, Cassisi NJ (1989) Postoperative irradiation for squamous cell carcinoma of the head and neck: an analysis of treatment results and complications. Int J Radiat Oncol Biol Phys 16:25-36 https://doi.org/10.1016/0360-3016(89)90006-0
  12. Dinshaw KA, Agarwal JP, Laskar SG, Gupta T, Shrivastava SK, Cruz AD (2005) Head and neck squamous cell carcinoma: the role of postoperative adjuvant radiotherapy. J Surg Oncol 91:48-55 https://doi.org/10.1002/jso.20274
  13. Brown JS, Shaw JR, Bekiroglu F, Rogers SN (2012) Systematic review of the current evidence in the use of postoperative radiotherapy for oral squamous cell carcinoma. Br J Oral Maxillofac Surg 6:481-489
  14. Hall J, Angele S (1999) Radiation, DNA damage and cancer. Mol Med Today 5(4):157-164 https://doi.org/10.1016/S1357-4310(99)01435-5
  15. Finlay PM, Dawson F, Robertson AG, Soutar DS (1992) An evaluation of functional outcome after surgery and radiotherapy for intraoral cancer. Br J Oral Maxillofac Surg 30:14-17 https://doi.org/10.1016/0266-4356(92)90130-B
  16. Lee JW, Kim JW, Kim CS (2008) A clinic-statistical study on cervical lymph node metastasis of oral squamous cell carcinoma. J Kor Oral Maxillofac Surg 34:594-601
  17. Rogers SN, Brown JS, Woolgar JA, Lowe D, Magennis P, Shaw RJ et al (2009) Survival following primary surgery for oral cancer. Oral Oncol 45:201-211 https://doi.org/10.1016/j.oraloncology.2008.05.008
  18. Padhye A, D'souza J (2011) Oral malignant melanoma: a silent killer? J of Ind Soci of Perio 4:425-428
  19. Auluck A, Zhang L, Desai R, Rosin MP (2008) Primary malignant melanoma of maxillary gingiva-a case report and review of the literature. J Can Dent Assoc 74(4):367-371
  20. Yamaguchi S, Nagasawa H, Suzuki T, Fujii E, Iwaki H, Takagi M et al (2004) Sarcomas of the oral and maxillofacial region: a review of 32 cases in 25 years. Clin Oral Investig 8:52-55
  21. Shah J, Gil Z (2009) Current concepts in management of oral cancer-surgery. Oral Oncol 45:394-401 https://doi.org/10.1016/j.oraloncology.2008.05.017
  22. Geum DH, Roh YC, Yoon SY, Kim HG, Lee JH, Song JM et al (2013) The impact factors on 5-year survival rate in patients operated with oral cancer. J Korean Assoc Oral Maxillofac Surg 5:207-216
  23. Schwartz GJ, Mehta RH, Wenig BL, Shaligram C, Louis G (2000) Salvage treatment for recurrent squamous cell carcinoma of the oral cavity. Head Neck 22(1):34-41 https://doi.org/10.1002/(SICI)1097-0347(200001)22:1<34::AID-HED6>3.0.CO;2-3

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