Child Health Nursing Research

  • 제22권4호
  • /
  • Pages.379-389
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  • 2016
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  • 2287-9110(pISSN)
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  • 2287-9129(eISSN)
한국아동간호학회 (Korean Academy of Child Health Nursing)
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고위험신생아의 생후 초기 구강 내 균집락 형성과 당농도 및 영향요인

Flora Colonization and Oral Glucose Levels During the Early Postnatal Period in High-Risk Newborns

  • 안영미 (인하대학교 간호학과) ;
  • 손민 (인하대학교 간호학과) ;
  • 전용훈 (인하대병원 소아청소년과) ;
  • 김남희 (인하대학교 간호학과)
  • 투고 : 2016.10.16
  • 심사 : 2016.10.25
  • 발행 : 2016.10.31
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초록

Purpose: A longitudinal study was conducted to explore flora colonization and oral glucose high-risk newborns during the first 7 days after birth. Methods: Oral secretions of hospitalized newborns were obtained for microbial cultures and glucose test at days 1-7 after birth. Results: Among the total 112 newborns, 40% were girls and 73% were premature. Mean gestational age was $34.4{\pm}3.2$ weeks and weight was $2,266{\pm}697.5$ grams. The most common flora included Streptococcus (28.2%), Methicillin-resistant Staphylococcus aureus (MRSA, 10.9%), Staphylococcus (6.0%) and Coagulase-Negative Staphylococcus (CNS, 4.0%). The average oral glucose level was $29.2{\pm}23.0mg/dL{\sim}58.2{\pm}39.5mg/dL$. Newborns with higher oral glucose than serum (crude odds ratio [ORc] =1.75; 95% confidence interval [CI] =1.03-2.97), phototherapy (ORc=3.30; 95% CI=2.29-4.76) and prone position (ORc= 2.04; 95% CI=1.13-3.69) were more likely to be colonized. Having oral tubes (ORc=0.42; 95% CI=0.29-0.59), parental nutrition (ORc=0.21; 95% CI=0.13-0.32) and antibiotics (ORc=0.51; 95% CI=0.36-0.73) had protective effects. For oral glucose statistical significances existed on time effect among newborns with Streptococcus (F=9.78, p=.024), MRSA (F=7.60, p=.037) or CNS (F=11.15, p=.019) and interaction between time and colonization among newborns with all of four flora (F=2.73, p=.029) or colonization with only Staphylococcus (F=2.91, p=.034). Conclusion: High-risk newborns develop flora colonization at an early period of life. Their clinical features were associated with types and time of oral flora colonization. They need close monitoring and multifaceted intervention to improve oral environment and infection control.

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참고문헌

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피인용 문헌

  1. 신생아 구강분비물의 당과 pH 및 영향 요인 탐색 vol.23, pp.3, 2016, https://doi.org/10.4094/chnr.2017.23.3.353