Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Effect of Valeriana fauriei Extract on the Neurodevelopmental Proteins Expression and Behavioral Patterns in Maternal Immune Activation Animal Model

쥐오줌풀 추출물이 MIA동물모델에서의 신경발달 단백질의 발현과 행동증상에 미치는 영향

  • Won, Hansol (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University) ;
  • Kim, Young Ock (Development of Ginseng and Medical Plants Research Institute, NIHHS, RDA) ;
  • Lee, Hwayoung (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University) ;
  • Im, Jiyun (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University) ;
  • Lee, Sanghyun (Department of Integrative Plant Science, Chungang University) ;
  • Cho, Ik Hyun (Department of Convergence Medical Science, Brain Korea 21 Plus Program, and Institute of Korean Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Lee, Sang Won (Development of Ginseng and Medical Plants Research Institute, NIHHS, RDA) ;
  • Park, Chun Geun (Development of Ginseng and Medical Plants Research Institute, NIHHS, RDA) ;
  • Kim, Hyung Ki (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University) ;
  • Kwon, Jun Tack (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University) ;
  • Kim, Hak Jae (Department of Clinical Pharmacology, College of Medicine, Soonchunhyang University)
  • 원한솔 (순천향대학교 의과대학 임상약리학교실) ;
  • 김영옥 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 이화영 (순천향대학교 의과대학 임상약리학교실) ;
  • 임지윤 (순천향대학교 의과대학 임상약리학교실) ;
  • 이상현 (중앙대학교 생명공학대학 식물시스템과학과) ;
  • 조익현 (경희대학교 한의과대학 융합의과학교실) ;
  • 이상원 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 박춘근 (농촌진흥청 국립원예특작과학원 인삼특작부) ;
  • 김형기 (순천향대학교 의과대학 임상약리학교실) ;
  • 권준택 (순천향대학교 의과대학 임상약리학교실) ;
  • 김학재 (순천향대학교 의과대학 임상약리학교실)
  • Received : 2016.08.19
  • Accepted : 2016.10.10
  • Published : 2016.10.30
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Abstract

Background: Prenatal exposure to infectious and/or inflammatory insults can increase the risk of developing neuropsychiatric disorder such as bipolar disorder, autism, and schizophrenia later in life. We investigated whether Valeriana fauriei (VF) treatment alleviates prepulse inhibition (PPI) deficits and social interaction impairment induced by maternal immune activation (MIA). Methods and Results: Pregnant mice were exposed to polyriboinosinic-polyribocytidilic acid (5 mg/kg, viral infection mimic) on gestational day 9. The adolescent offspring received daily oral treatment with VF (100 mg/kg) and injections of clozapine (5 mg/kg) for 30 days starting on the postnatal day 35. The effects of VF extract treatment on behavioral activity impairment and protein expression were investigated using the PPI analysis, forced swim test (FST), open field test (OFT), social interaction test (SIT), and immunohistochemistry. The MIA-induced offspring showed deficits in the PPI, FST, OFT, and SIT compared to their non MIA-induced counterparts. Treatment with the VF extract significantly recovered the sensorimotor gating deficits and partially recovered the aggressive behavior observed in the SIT. The VF extract also reversed the downregulation of protein expression induced by MIA in the medial prefrontal cortex. Conclusions: Our results provide initial evidence of the fact that the VF extract could reverse MIA-induced behavioral impairment and prevent neurodevelopmental disorders such as schizophrenia.

Keywords

References

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