Journal of Cardiovascular Imaging

  • 제24권2호
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  • Pages.128-134
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  • 2016
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  • 2586-7210(pISSN)
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  • 2586-7296(eISSN)
한국심초음파학회 (Korean Society of Echocardiography)
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Echocardiographic Predictors for Left Ventricular Remodeling after Acute ST Elevation Myocardial Infarction with Low Risk Group: Speckle Tracking Analysis

  • Na, Hyun-Min (College of Medicine, Seoul National University) ;
  • Cho, Goo-Yeong (Cardiovascular Center, Seoul National University Bundang Hospital) ;
  • Lee, Joo Myung (Cardiovascular Center, Seoul National University Hospital) ;
  • Cha, Myung-Jin (Cardiovascular Center, Seoul National University Hospital) ;
  • Yoon, Yeonyee E. (Cardiovascular Center, Seoul National University Bundang Hospital) ;
  • Lee, Seung-Pyo (Cardiovascular Center, Seoul National University Hospital) ;
  • Kim, Hyung-Kwan (Cardiovascular Center, Seoul National University Hospital) ;
  • Kim, Yong-Jin (Cardiovascular Center, Seoul National University Hospital) ;
  • Sohn, Dae-Won (Cardiovascular Center, Seoul National University Hospital)
  • 투고 : 2016.01.18
  • 심사 : 2016.05.10
  • 발행 : 2016.06.27
⟨ 이전 논문 다음 논문 ⟩

초록

Background: We sought to assess echocardiographic predictors of left ventricular (LV) adverse remodeling after successfully reperfused acute ST elevation myocardial infarction (STEMI). LV remodeling is commonly found in STEMI patients and it may suggest adverse outcome in acute myocardial infarction. We sought to identify whether 2D strain and torsion be independent parameters for prediction of LV adverse remodeling. Methods: We investigated 208 patients with low-risk STEMI patients who had follow up echocardiography at 6 or more months. After clinical assessments, all patients received revascularization according to current guideline. LV remodeling was defined as > 20% increase in end-diastolic volume (EDV) at follow up. Results: During the follow-up ($11.9{\pm}5.3$ months), 53 patients (25.5%) showed LV remodeling. In univariate analysis, EDV, end-systolic volume, deceleration time (DT), CK-MB, and global longitudinal strain (GLS) were associated with LV remodeling. In multivariate analysis, EDV [hazard ratio (HR): 0.922, 95% confidence interval (CI): 0.897-0.948, p < 0.001], GLS (HR: 0.842, 95% CI: 0.728-0.974, p = 0.020), DT (HR: 0.989, 95% CI: 0.980-0.998, p = 0.023) and CK-MB (HR: 1.003, 95% CI: 1.000-1.005, p = 0.033) independently predicted LV remodeling. However, global circumferential strain, net twist, and twist or untwist rate were not associated with remodeling. Conclusion: Of various parameters of speckle strain, only GLS predicted adverse remodeling in STEMI patients.

키워드

과제정보

연구 과제 주관 기관 : SNUBH

참고문헌

  1. Curtis JP, Sokol SI, Wang Y, Rathore SS, Ko DT, Jadbabaie F, Portnay EL, Marshalko SJ, Radford MJ, Krumholz HM. The association of left ventricular ejection fraction, mortality, and cause of death in stable outpatients with heart failure. J Am Coll Cardiol 2003;42:736-42. https://doi.org/10.1016/S0735-1097(03)00789-7
  2. Thune JJ, Kober L, Pfeffer MA, Skali H, Anavekar NS, Bourgoun M, Ghali JK, Arnold JM, Velazquez EJ, Solomon SD. Comparison of regional versus global assessment of left ventricular function in patients with left ventricular dysfunction, heart failure, or both after myocardial infarction: the valsartan in acute myocardial infarction echocardiographic study. J Am Soc Echocardiogr 2006;19:1462-5. https://doi.org/10.1016/j.echo.2006.05.028
  3. Burns RJ, Gibbons RJ, Yi Q, Roberts RS, Miller TD, Schaer GL, Anderson JL, Yusuf S; CORE Study Investigators. The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis. J Am Coll Cardiol 2002;39:30-6.
  4. McDermott MM, Feinglass J, Lee PI, Mehta S, Schmitt B, Lefevre F, Gheorghiade M. Systolic function, readmission rates, and survival among consecutively hospitalized patients with congestive heart failure. Am Heart J 1997;134:728-36. https://doi.org/10.1016/S0002-8703(97)70057-7
  5. Moller JE, Hillis GS, Oh JK, Reeder GS, Gersh BJ, Pellikka PA. Wall motion score index and ejection fraction for risk stratification after acute myocardial infarction. Am Heart J 2006;151:419-25. https://doi.org/10.1016/j.ahj.2005.03.042
  6. Thomas JD, Popovic ZB. Assessment of left ventricular function by cardiac ultrasound. J Am Coll Cardiol 2006;48:2012-25. https://doi.org/10.1016/j.jacc.2006.06.071
  7. Gaudron P, Eilles C, Kugler I, Ertl G. Progressive left ventricular dysfunction and remodeling after myocardial infarction. Potential mechanisms and early predictors. Circulation 1993;87:755-63. https://doi.org/10.1161/01.CIR.87.3.755
  8. Shin SH, Hung CL, Uno H, Hassanein AH, Verma A, Bourgoun M, Kober L, Ghali JK, Velazquez EJ, Califf RM, Pfeffer MA, Solomon SD; Valsartan in Acute Myocardial Infarction Trial (VALIANT) Investigators. Mechanical dyssynchrony after myocardial infarction in patients with left ventricular dysfunction, heart failure, or both. Circulation 2010;121:1096-103. https://doi.org/10.1161/CIRCULATIONAHA.109.863795
  9. Svealv BG, Olofsson EL, Andersson B. Ventricular long-axis function is of major importance for long-term survival in patients with heart failure. Heart 2008;94:284-9. https://doi.org/10.1136/hrt.2006.106294
  10. St John Sutton M, Lee D, Rouleau JL, Goldman S, Plappert T, Braunwald E, Pfeffer MA. Left ventricular remodeling and ventricular arrhythmias after myocardial infarction. Circulation 2003;107:2577-82.
  11. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation 1990;81:1161-72. https://doi.org/10.1161/01.CIR.81.4.1161
  12. Langeland S, D'hooge J, Wouters PF, Leather HA, Claus P, Bijnens B, Sutherland GR. Experimental validation of a new ultrasound method for the simultaneous assessment of radial and longitudinal myocardial deformation independent of insonation angle. Circulation 2005;112:2157-62. https://doi.org/10.1161/CIRCULATIONAHA.105.554006
  13. Leitman M, Lysyansky P, Sidenko S, Shir V, Peleg E, Binenbaum M, Kaluski E, Krakover R, Vered Z. Two-dimensional strain-a novel software for real-time quantitative echocardiographic assessment of myocardial function. J Am Soc Echocardiogr 2004;17:1021-9. https://doi.org/10.1016/j.echo.2004.06.019
  14. Notomi Y, Lysyansky P, Setser RM, Shiota T, Popovic ZB, Martin- Miklovic MG, Weaver JA, Oryszak SJ, Greenberg NL, White RD, Thomas JD. Measurement of ventricular torsion by two-dimensional ultrasound speckle tracking imaging. J Am Coll Cardiol 2005;45:2034-41. https://doi.org/10.1016/j.jacc.2005.02.082
  15. Amundsen BH, Helle-Valle T, Edvardsen T, Torp H, Crosby J, Lyseggen E, Stoylen A, Ihlen H, Lima JA, Smiseth OA, Slordahl SA. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol 2006;47:789-93. https://doi.org/10.1016/j.jacc.2005.10.040
  16. Hanekom L, Jenkins C, Jeffries L, Case C, Mundy J, Hawley C, Marwick TH. Incremental value of strain rate analysis as an adjunct to wall-motion scoring for assessment of myocardial viability by dobutamine echocardiography: a follow-up study after revascularization. Circulation 2005;112:3892-900. https://doi.org/10.1161/CIRCULATIONAHA.104.489310
  17. Hung CL, Verma A, Uno H, Shin SH, Bourgoun M, Hassanein AH, McMurray JJ, Velazquez EJ, Kober L, Pfeffer MA, Solomon SD; VALIANT investigators. Longitudinal and circumferential strain rate, left ventricular remodeling, and prognosis after myocardial infarction. J Am Coll Cardiol 2010;56:1812-22. https://doi.org/10.1016/j.jacc.2010.06.044
  18. Stanton T, Leano R, Marwick TH. Prediction of all-cause mortality from global longitudinal speckle strain: comparison with ejection fraction and wall motion scoring. Circ Cardiovasc Imaging 2009;2:356-64. https://doi.org/10.1161/CIRCIMAGING.109.862334
  19. Park YH, Kang SJ, Song JK, Lee EY, Song JM, Kang DH, Kim YH, Lee CW, Hong MK, Kim JJ, Park SW, Park SJ. Prognostic value of longitudinal strain after primary reperfusion therapy in patients with anterior-wall acute myocardial infarction. J Am Soc Echocardiogr 2008; 21:262-7. https://doi.org/10.1016/j.echo.2007.08.026
  20. Lacalzada J, de la Rosa A, Izquierdo MM, Jimenez JJ, Iribarren JL, Garcia-Gonzalez MJ, Lopez BM, Duque MA, Barragan A, Hernandez C, Carrillo-Perez M, Laynez I. Left ventricular global longitudinal systolic strain predicts adverse remodeling and subsequent cardiac events in patients with acute myocardial infarction treated with primary percutaneous coronary intervention. Int J Cardiovasc Imaging 2015;31:575-84. https://doi.org/10.1007/s10554-015-0593-2
  21. Wang J, Khoury DS, Yue Y, Torre-Amione G, Nagueh SF. Preserved left ventricular twist and circumferential deformation, but depressed longitudinal and radial deformation in patients with diastolic heart failure. Eur Heart J 2008;29:1283-9.
  22. Nucifora G, Marsan NA, Bertini M, Delgado V, Siebelink HM, van Werkhoven JM, Scholte AJ, Schalij MJ, van der Wall EE, Holman ER, Bax JJ. Reduced left ventricular torsion early after myocardial infarction is related to left ventricular remodeling. Circ Cardiovasc Imaging 2010; 3:433-42. https://doi.org/10.1161/CIRCIMAGING.109.926196
  23. Bochenek T, Wita K, Tabor Z, Grabka M, Krzych L, Wrobel W, Berger-Kucza A, Elzbieciak M, Doruchowska A, Gluza MT. Value of speckle-tracking echocardiography for prediction of left ventricular remodeling in patients with ST-elevation myocardial infarction treated by primary percutaneous intervention. J Am Soc Echocardiogr 2011;24:1342-8. https://doi.org/10.1016/j.echo.2011.09.003
  24. Cho GY, Marwick TH, Kim HS, Kim MK, Hong KS, Oh DJ. Global 2-dimensional strain as a new prognosticator in patients with heart failure. J Am Coll Cardiol 2009;54:618-24. https://doi.org/10.1016/j.jacc.2009.04.061
  25. Reimer KA, Lowe JE, Rasmussen MM, Jennings RB. The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs. Circulation 1977;56:786-94. https://doi.org/10.1161/01.CIR.56.5.786
  26. Mizuguchi Y, Oishi Y, Miyoshi H, Iuchi A, Nagase N, Oki T. The functional role of longitudinal, circumferential, and radial myocardial deformation for regulating the early impairment of left ventricular contraction and relaxation in patients with cardiovascular risk factors: a study with two-dimensional strain imaging. J Am Soc Echocardiogr 2008;21:1138-44. https://doi.org/10.1016/j.echo.2008.07.016
  27. Reant P, Labrousse L, Lafitte S, Bordachar P, Pillois X, Tariosse L, Bonoron-Adele S, Padois P, Deville C, Roudaut R, Dos Santos P. Experimental validation of circumferential, longitudinal, and radial 2-dimensional strain during dobutamine stress echocardiography in ischemic conditions. J Am Coll Cardiol 2008;51:149-57. https://doi.org/10.1016/j.jacc.2007.07.088
  28. Abate E, Hoogslag GE, Leong DP, Bertini M, Antoni ML, Nucifora G, Joyce E, Holman ER, Siebelink HM, Schalij MJ, Bax JJ, Delgado V, Ajmone Marsan N. Association between multilayer left ventricular rotational mechanics and the development of left ventricular remodeling after acute myocardial infarction. J Am Soc Echocardiogr 2014;27:239-48. https://doi.org/10.1016/j.echo.2013.12.009
  29. Choi JO, Shin MS, Kim MJ, Jung HO, Park JR, Sohn IS, Kim H, Park SM, Yoo NJ, Choi JH, Kim HK, Cho GY, Lee MR, Park JS, Shim CY, Kim DH, Shin DH, Shin GJ, Shin SH, Kim KH, Park JH, Lee SY, Kim WS, Park SW. Normal echocardiographic measurements in a Korean population study: part I. Cardiac chamber and great artery evaluation. J Cardiovasc Ultrasound 2015;23:158-72. https://doi.org/10.4250/jcu.2015.23.3.158
  30. Seo Y, Ishizu T, Aonuma K. Current status of 3-dimensional speckle tracking echocardiography: a review from our experiences. J Cardiovasc Ultrasound 2014;22:49-57. https://doi.org/10.4250/jcu.2014.22.2.49

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