Journal of Cardiovascular Imaging

  • 제24권2호
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  • Pages.115-122
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  • 2016
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  • 2586-7210(pISSN)
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  • 2586-7296(eISSN)
한국심초음파학회 (Korean Society of Echocardiography)
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The Combined Impact of Neutrophil-to-Lymphocyte Ratio and Type 2 Diabetic Mellitus on Significant Coronary Artery Disease and Carotid Artery Atherosclerosis

  • Kim, Bong-Joon (Division of Cardiology, Department of Internal Medicine, Convergence Medicine & Exercise Science Research Institute, Kosin University School of Medicine) ;
  • Cho, Sang-Hoon (Department of Statistics and Actuarial Science, Soongsil University) ;
  • Cho, Kyoung-Im (Division of Cardiology, Department of Internal Medicine, Convergence Medicine & Exercise Science Research Institute, Kosin University School of Medicine) ;
  • Kim, Hyun-Su (Division of Cardiology, Department of Internal Medicine, Convergence Medicine & Exercise Science Research Institute, Kosin University School of Medicine) ;
  • Heo, Jung-Ho (Division of Cardiology, Department of Internal Medicine, Convergence Medicine & Exercise Science Research Institute, Kosin University School of Medicine) ;
  • Cha, Tae-Joon (Division of Cardiology, Department of Internal Medicine, Convergence Medicine & Exercise Science Research Institute, Kosin University School of Medicine)
  • 투고 : 2015.11.10
  • 심사 : 2016.05.10
  • 발행 : 2016.06.27
⟨ 이전 논문 다음 논문 ⟩

초록

Background: Neutrophil-to-lymphocyte ratio (NLR) has recently emerged as a new important inflammatory marker for predicting cardiovascular events. This study aimed to evaluate the combined impact of NLR and type 2 diabetes mellitus (T2DM) on significant coronary artery disease (CAD) and carotid artery atherosclerosis. Methods: This study includes a total of 828 patients evaluated by coronary angiography and carotid ultrasonography. Significant CAD was defined as at least one vessel with stenosis greater than 50%. We employed logistic regression models to investigate the association of NLR and T2DM with significant CAD. The goodness-of-fit and discriminability of the models were assessed by the loglikelihood ratio test and C-index, respectively. Also, we investigated the clinical relevance of the categorized NLR that classifies patients into three risk groups (low, intermediate, high). Results: According to logistic regression analysis, both NLR [adjusted odds ratio (OR) 1.31, p < 0.001] and T2DM (adjusted OR 2.46, p = 0.006) were independent risk factors of significant CAD. The addition of NLR and T2DM into a logistic regression model including conventional cardiovascular risk factors significantly improved the goodness-of-fit (p < 0.001) and the discriminability of the model (p = 0.004). Also, T2DM patients assigned into the high risk group (NLR > 2) showed the greater prevalence of significant CAD and carotid artery atherosclerosis compared with patients without T2DM or type 2 diabetic patients assigned into the low risk group ($NLR{\leq}1$). Conclusion: Our results suggest that type 2 diabetic patients with high inflammatory state would be more vulnerable to significant CAD and carotid artery atherosclerosis.

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과제정보

연구 과제 주관 기관 : Kosin University College of Medicine

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