Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
권호 표지
DOI QR코드

DOI QR Code

A Rare Case of Viagra Induced Toxic Encephalopathy

  • Jeong, Soo Yeon (Department of Radiology, Wonkwang University Hospital) ;
  • Jeon, Se Jeong (Department of Radiology, Wonkwang University Hospital) ;
  • Kim, Youe Ree (Department of Radiology, Wonkwang University Hospital) ;
  • Choi, See-Sung (Department of Radiology, Wonkwang University Hospital) ;
  • Kwak, Hyo Sung (Department of Radiology, Chonbuk National University Hospital)
  • Received : 2016.07.27
  • Accepted : 2016.09.19
  • Published : 2016.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Viagra has been prescribed worldwide to treat men with erectile dysfunction. Clinical trials have shown that Viagra may cause various kinds of adverse effects include some central nervous system (CNS) adverse effects. Although extremely rare, toxic encephalopathy also can be one of those effects. This report presents a case of encephalopathy caused by Viagra in correlation with its radiologic findings. Its pharmacologic mechanism and potential effects on the biochemistry of the CNS are reviewed.

Keywords

References

  1. Viagra U.S. Physician Prescribing Information and U.S. Patient Product Information. Pfizer Laboratories Div Pfized Inc, September 2015
  2. Milman HA, Arnold SB. Neurologic, psychological, and aggressive disturbances with sildenafil. Ann Pharmacother 2002;36:1129-1134 https://doi.org/10.1345/aph.1A402
  3. Drug Information for the Health Care Professional. Sildenafil USP DI 2000, 20th ed. Thompson Healthcare, 2000;1:2772-2775
  4. Corbin JD. Mechanisms of action of PDE5 inhibition in erectile dysfunction. Int J Impot Res 2004;16 Suppl 1:S4-7 https://doi.org/10.1038/sj.ijir.3901205
  5. Review: Could Viagra cause toxic induced encephalopathy? http://www.ehealthme.com/ds/viagra/toxic%20induced%20encephalopathy/. Accessed September 29, 2016
  6. Kang E, Jeon SJ, Choi SS. Uremic encephalopathy with atypical magnetic resonance features on diffusionweighted images. Korean J Radiol 2012;13:808-811 https://doi.org/10.3348/kjr.2012.13.6.808
  7. Bathla G, Policeni B, Agarwal A. Neuroimaging in patients with abnormal blood glucose levels. AJNR Am J Neuroradiol 2014;35:833-840
  8. Knowles RG, Palacios M, Palmer RM, Moncada S. Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase. Proc Natl Acad Sci U S A 1989;86:5159-5162 https://doi.org/10.1073/pnas.86.13.5159