Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Screening of 50 Korean Herbal formulas with Inhibitory Effects on Acetylcholinesterase Activity and Amyloid-β Aggregation

다빈도 한약 처방 50종의 아세틸콜린 분해 효소 활성 및 아밀로이드 베타 단백질 응집 억제 효능 비교 연구

  • Lim, Hye-Sun (Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Yoonju (Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Kim, Ohn Soon (Herbal Medicine Research Division, Korea Institute of Oriental Medicine) ;
  • Jeong, Soo-Jin (Herbal Medicine Research Division, Korea Institute of Oriental Medicine)
  • 임혜선 (한국한의학연구원 한의약융합연구부) ;
  • 김윤주 (한국한의학연구원 한의약융합연구부) ;
  • 김온순 (한국한의학연구원 한의약융합연구부) ;
  • 정수진 (한국한의학연구원 한의약융합연구부)
  • Received : 2016.06.23
  • Accepted : 2016.08.16
  • Published : 2016.09.30
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Abstract

Acetylcholinesterase (AChE) activation and amyloid-${\beta}$ ($A{\beta}$) aggregation are major biological markers of Alzheimer's disease. In the present study, we evaluated the inhibitory effects of 50 kinds of herbal formulas on AChE activity and $A{\beta}$ aggregation. Among them, Hwanglyeonhaedok-tang, Cheonwangbosim-dan, Makmundong-tang, and Gamisoyo-san had a potent effects on the inhbition of AChE activity. Sosiho-tang, Samsoeum, Cheonsimyeunjaeum, and Bunsimgieum exerted to have the inhibitory activity on $A{\beta}$ aggregation. In addition, these 8 herbal formulas showed the 3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity, indicating their antioxidant activities.

Keywords

References

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