Clinical and Experimental Reproductive Medicine

  • 제43권3호
  • /
  • Pages.164-168
  • /
  • 2016
  • /
  • 2233-8233(pISSN)
  • /
  • 2233-8241(eISSN)
대한생식의학회 (The Korean Society for Reproductive Medicine)
권호 표지
DOI QR코드

DOI QR Code

Clinical outcomes of single versus double blastocyst transfer in fresh and vitrified-warmed cycles

  • Eum, Jin Hee (Fertility Center of CHA Gangnam Medical Center, College of Medicine, CHA University) ;
  • Park, Jae Kyun (Fertility Center of CHA Gangnam Medical Center, College of Medicine, CHA University) ;
  • Kim, So Young (Fertility Center of CHA Gangnam Medical Center, College of Medicine, CHA University) ;
  • Paek, Soo Kyung (Fertility Center of CHA Gangnam Medical Center, College of Medicine, CHA University) ;
  • Seok, Hyun Ha (Fertility Center of CHA Gangnam Medical Center, College of Medicine, CHA University) ;
  • Chang, Eun Mi (Fertility Center of CHA Gangnam Medical Center, College of Medicine, CHA University) ;
  • Lee, Dong Ryul (Fertility Center of CHA Gangnam Medical Center, College of Medicine, CHA University) ;
  • Lee, Woo Sik (Fertility Center of CHA Gangnam Medical Center, College of Medicine, CHA University)
  • 투고 : 2016.02.19
  • 심사 : 2016.05.30
  • 발행 : 2016.09.22
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: Assisted reproductive technology has been associated with an increase in multiple pregnancies. The most effective strategy for reducing multiple pregnancies is single embryo transfer. Beginning in October 2015, the National Supporting Program for Infertility in South Korea has limited the number of embryos that can be transferred per in vitro fertilization (IVF) cycle depending on the patient's age. However, little is known regarding the effect of age and number of transferred embryos on the clinical outcomes of Korean patients. Thus, this study was performed to evaluate the effect of the number of transferred blastocysts on clinical outcomes. Methods: This study was carried out in the Fertility Center of CHA Gangnam Medical Center from January 2013 to December 2014. The clinical outcomes of 514 women who underwent the transfer of one or two blastocysts on day 5 after IVF and of 721 women who underwent the transfer of one or two vitrified-warmed blastocysts were analyzed retrospectively. Results: For both fresh and vitrified-warmed cycles, the clinical pregnancy rate and live birth or ongoing pregnancy rate were not significantly different between patients who underwent elective single blastocyst transfer (eSBT) and patients who underwent double blastocyst transfer (DBT), regardless of age. However, the multiple pregnancy rate was significantly lower in the eSBT group than in the DBT group. Conclusion: The clinical outcomes of eSBT and DBT were equivalent, but eSBT had a lower risk of multiple pregnancy and is, therefore, the best option.

키워드

참고문헌

  1. Ministry of Health and Welfare. A study for the improvement of sub-fertility couple supporting program [Internet]. Sejong: Ministry of Health and Welfare; 2013 [cited 2013 Nov 29]. Available from: http://www.prism.go.kr/.
  2. Van Voorhis BJ. Clinical practice: in vitro fertilization. N Engl J Med 2007;356:379-86. https://doi.org/10.1056/NEJMcp065743
  3. Statistics Korea. Final results of birth statistics in 2014 [Internet]. Daejeon: Statistics Korea; 2015 [cited 2015 August 25]. Available from: http://kostat.go.kr/portal/korea/.
  4. Schieve LA, Meikle SF, Ferre C, Peterson HB, Jeng G, Wilcox LS. Low and very low birth weight in infants conceived with use of assisted reproductive technology. N Engl J Med 2002;346:731-7. https://doi.org/10.1056/NEJMoa010806
  5. D'Angelo DV, Whitehead N, Helms K, Barfield W, Ahluwalia IB. Birth outcomes of intended pregnancies among women who used assisted reproductive technology, ovulation stimulation, or no treatment. Fertil Steril 2011;96:314-20.e2. https://doi.org/10.1016/j.fertnstert.2011.05.073
  6. Messerlian C, Maclagan L, Basso O. Infertility and the risk of adverse pregnancy outcomes: a systematic review and meta-analysis. Hum Reprod 2013;28:125-37. https://doi.org/10.1093/humrep/des347
  7. Janvier A, Spelke B, Barrington KJ. The epidemic of multiple gestations and neonatal intensive care unit use: the cost of irresponsibility. J Pediatr 2011;159:409-13. https://doi.org/10.1016/j.jpeds.2011.02.017
  8. Practice Committee of American Society for Reproductive Medicine. Multiple gestation associated with infertility therapy: an American Society for Reproductive Medicine Practice Committee opinion. Fertil Steril 2012;97:825-34. https://doi.org/10.1016/j.fertnstert.2011.11.048
  9. Ombelet W, De Sutter P, Van der Elst J, Martens G. Multiple gestation and infertility treatment: registration, reflection and reaction– the Belgian project. Hum Reprod Update 2005;11:3-14. https://doi.org/10.1093/humupd/dmh048
  10. Henderson CE, Scarpelli S, LaRosa D, Divon MY. Assessing the risk of gestational diabetes in twin gestation. J Natl Med Assoc 1995;87:757-8.
  11. Berin I, McLellan ST, Macklin EA, Toth TL, Wright DL. Frozenthawed embryo transfer cycles: clinical outcomes of single and double blastocyst transfers. J Assist Reprod Genet 2011;28:575-81. https://doi.org/10.1007/s10815-011-9551-7
  12. McLernon DJ, Harrild K, Bergh C, Davies MJ, de Neubourg D, Dumoulin JC, et al. Clinical effectiveness of elective single versus double embryo transfer: meta-analysis of individual patient data from randomised trials. BMJ 2010;341:c6945. https://doi.org/10.1136/bmj.c6945
  13. Alansari L, Akande V. How to maximize the pregnancy rate with no increase in multiple pregnancy rates following blastocyst embryo transfer? Is blastocyst transfer time the missing ingredient? Middle East Fertil Soc J 2015;20:241-5. https://doi.org/10.1016/j.mefs.2015.02.002
  14. Forman EJ, Hong KH, Ferry KM, Tao X, Taylor D, Levy B, et al. In vitro fertilization with single euploid blastocyst transfer: a randomized controlled trial. Fertil Steril 2013;100:100-7.e1. https://doi.org/10.1016/j.fertnstert.2013.02.056

피인용 문헌

  1. Extended culture of poor-quality supernumerary embryos improves ART outcomes vol.35, pp.2, 2018, https://doi.org/10.1007/s10815-017-1063-7
  2. One Plus One Is Better Than Two: Cumulative Reproductive Outcomes Are Better after Two Elective Single Blastocyst Embryo Transfers Compared to One Double Blastocyst Embryo Transfer vol.11, pp.2, 2016, https://doi.org/10.4103/jhrs.jhrs_117_17
  3. Single fresh blastocyst transfer or single cryopreserved-thawed blastocyst transfer: which is preferable for infertile patients in IVF/ICSI cycles? A meta-analysis vol.35, pp.1, 2016, https://doi.org/10.1080/09513590.2018.1490408
  4. Related Factors and Research Progress of Premature Birth after Assisted Reproductive Technology vol.9, pp.10, 2016, https://doi.org/10.12677/acm.2019.910172
  5. Single and double embryo transfer provide similar live birth rates in frozen cycles vol.36, pp.9, 2016, https://doi.org/10.1080/09513590.2020.1712697
  6. Live birth rate and neonatal outcomes of different quantities and qualities of frozen transferred blastocyst in patients requiring whole embryo freezing stratified by age vol.20, pp.1, 2016, https://doi.org/10.1186/s12884-020-03353-5
  7. Believing that transferring more embryos will result in increased pregnancy rates: a flawed concept: a SWOT analysis vol.25, pp.1, 2016, https://doi.org/10.1186/s43043-020-00042-3