Natural Product Sciences

  • 제22권3호
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  • Pages.216-219
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  • 2016
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  • 1226-3907(pISSN)
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  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
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New Production of Antibacterial Polycyclic Quinazoline Alkaloid, Thielaviazoline, from Anthranilic Acid by the Marine-Mudflat-Derived Fungus Thielavia sp.

  • 투고 : 2016.03.07
  • 심사 : 2016.04.11
  • 발행 : 2016.09.30
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초록

The microbial transformation of anthranilic acid (1) by the marine-mudflat-derived fungus Thielavia sp. produced an antibacterial polycyclic quinazoline alkaloid, thielaviazoline (2). The stereostructure of the metabolite was assigned based on detailed spectroscopic data analyses including comparison of the NMR ($^1H$ and $^{13}C$) data with those of reported compound (2). Compound 2 displayed in vitro antimicrobial activity against methicillin-resistant and multidrug-resistant Staphylococcus aureus (MRSA and MDRSA), with minimum inhibitory concentrations (MICs) of 6.25 and $12.5{\mu}g/mL$, respectively. Compound 2 also showed potent radical-scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) with an $IC_{50}$ of $11{\mu}M$, which was more active than the positive control, L-ascorbic acid ($IC_{50}$, $20.0{\mu}M$).

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피인용 문헌

  1. Fungal Diversity in Intertidal Mudflats and Abandoned Solar Salterns as a Source for Biological Resources vol.17, pp.11, 2016, https://doi.org/10.3390/md17110601
  2. Alkaloids from Marine Fungi: Promising Antimicrobials vol.9, pp.6, 2016, https://doi.org/10.3390/antibiotics9060340
  3. Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies vol.19, pp.2, 2021, https://doi.org/10.3390/md19020088
  4. Comprehensive Overview on the Chemistry and Biological Activities of Selected Alkaloid Producing Marine-Derived Fungi as a Valuable Reservoir of Drug Entities vol.9, pp.5, 2021, https://doi.org/10.3390/biomedicines9050485