전자공학회논문지 (Journal of the Institute of Electronics and Information Engineers)

  • 제53권9호
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  • Pages.99-109
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  • 2016
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  • 2287-5026(pISSN)
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  • 2288-159X(eISSN)
대한전자공학회 (The Institute of Electronics and Information Engineers)
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미소혈관내 백혈구 운동검출을 위한 시공간 영상 생성법

Generation Method of Spatiotemporal Image for Detecting Leukocyte Motions in a Microvessel

  • 김응규 (한밭대학교 정보통신공학과)
  • Kim, Eung Kyeu (Dept. of Information and Communication Eng., Hanbat National University)
  • 투고 : 2015.12.06
  • 심사 : 2016.08.27
  • 발행 : 2016.09.25
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초록

본 논문에서는 미소혈관내 백혈구 운동을 검출하기 위한 시공간 영상을 생성하는 방법을 제안한다. 백혈구는 혈관벽의 윤곽선을 따라 움직인다는 구속조건을 사용하여 백혈구 운동을 검출하고 시공간 영상을 생성한다. 우선, 생체내의 운동에 의해 발생한 평행운동을 템플레이트 정합법으로 제거한다. 다음으로, 시간 분산 영상을 이진화하기 위한 자동 문턱값 선정법에 기초하여 혈관 영역을 검출하고 그 다음, 혈관벽 윤곽선을 B-스플라인 함수로 나타낸다. 최종적으로, 검출된 혈관벽 윤곽선을 초기곡선으로하여 가장 정확한 위치의 혈장층을 스네이크에 의한 공간축으로 결정하고 시공간 영상을 생성한다. 실험 결과, 제안방법은 세개 영상 계열의 각 단계별 비교를 통해 시공간 영상을 양호하게 생성함을 보여준다.

This paper presents a method for generating spatiotemporal images to detect the leukocyte motions in a microvessel. By using the constraint that the leukocytes move along the contour line of a blood vessel wall, the method detects leukocyte motions and then generates spatiotemporal images. the translational motion by a movement in vivo is removed first by the template matching method. Next, a blood vessel region is detected by the automatic threshold selection method to binarize the temporal variance image, then a blood vessel wall's contour is expressed by B-spline function. With the detected blood vessel wall's contour as an initial curve, the plasma layer of the best accurate position is determined to be the spatial axis by snake. Finally, the spatiotemporal images are generated. The experimental results show the spatiotemporal images are generated effectively through the comparison of each step of three image sequences.

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