Korean Circulation Journal

  • 제46권3호
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  • Pages.384-393
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  • 2016
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
권호 표지
DOI QR코드

DOI QR Code

Medication Adherence and the Occurrence of Complications in Patients with Newly Diagnosed Hypertension

  • Kim, Hyun-Jin (Department of Rehabilitation Standard & Policy, Korea National Rehabilitation Research Institute) ;
  • Yoon, Seok-Jun (Department of Preventive Medicine, Korea University College of Medicine) ;
  • Oh, In-Hwan (Department of Preventive Medicine, Kyung Hee University College of Medicine) ;
  • Lim, Jae Hee (Department of Preventive Medicine, Kyung Hee University College of Medicine) ;
  • Kim, Young Ae (Cancer Policy Branch, National Cancer Control Institute, National Cancer Center)
  • 투고 : 2015.03.30
  • 심사 : 2015.11.17
  • 발행 : 2016.05.30
⟨ 이전 논문 다음 논문 ⟩

초록

Background and Objectives: In this retrospective cohort study, we sought to elucidate the relationship between medication adherence (MA) and the incidence of complications in patients with newly diagnosed hypertension. Subjects and Methods: Using claims data from the National Health Insurance Service, we measured health outcomes based on levels of MA, analyzed the incidence of complications in patients with a good MA, and clarified factors that may affect or predict MA. Results: In 2008, a total of 4294773 patients were diagnosed with hypertension and were subsequently prescribed anti-hypertensive medications. In the present study, we enrolled 564782 patients who met our inclusion/exclusion criteria. The 40-59% medication possession ratio (MPR) group had a 1.36 times higher risk of developing complications (95% confidence interval [CI]: 1.27-1.45) than did the $MPR{\geq}80%$ group, as revealed through Cox's proportional hazards analysis. Similarly, the <20% MPR group was 2.01 times more likely to develop complications than the good MA group (95% CI: 1.82-2.23). Overall, patients who had a lower level of MA had a higher risk of developing complications. Conclusion: Our results demonstrate that MA is tightly correlated with hypertension health outcomes. Improving MA could be one strategy for reducing the risk of cerebrovascular disease complications and the loss of productivity in these patients.

키워드

과제정보

연구 과제 주관 기관 : Ministry of Health & Welfare

참고문헌

  1. Cade WT. Diabetes-related microvascular and macrovascular diseases in the physical therapy setting. Phys Ther 2008;88:1322-35. https://doi.org/10.2522/ptj.20080008
  2. Kim HJ, Kim YA, Seo HY, Kim EJ, Yoon SJ, Oh IH. The economic burden of stroke in 2010 in Korea. J Korean Med Assoc 2012;55:1226-36. https://doi.org/10.5124/jkma.2012.55.12.1226
  3. Heidenreich PA, Trogdon JG, Khavjou OA, et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American heart association. Circulation 2011;123:933-44. https://doi.org/10.1161/CIR.0b013e31820a55f5
  4. Kang JH, Jeong BG, Cho YG, Song HR, Kim KA. Socioeconomic costs of overweight and obesity in Korean adults. J Korean Med Sci 2011;26:1533-40. https://doi.org/10.3346/jkms.2011.26.12.1533
  5. Brown MT, Bussell JK. Medication adherence: WHO cares? Mayo Clin Proc 2011;86:304-14. https://doi.org/10.4065/mcp.2010.0575
  6. Dreiher J, Comaneshter DS, Rosenbluth Y, Battat E, Bitterman H, Cohen AD. The association between continuity of care in the community and health outcomes: a population-based study. Isr J Health Policy Res 2012;1:21. https://doi.org/10.1186/2045-4015-1-21
  7. Vlasnik JJ, Aliotta SL, DeLor B. Medication adherence: factors influencing compliance with prescribed medication plans. Case Manager 2005;16:47-51.
  8. Staessen JA, Wang JG, Thijs L. Cardiovascular protection and blood pressure reduction: a meta-analysis. Lancet 2001;358:1305-15. https://doi.org/10.1016/S0140-6736(01)06411-X
  9. Jin J, Sklar GE, Min Sen Oh V, Chuen Li S. Factors affecting therapeutic compliance: a review from the patient's perspective. Ther Clin Risk Manag 2008;4:269-86. https://doi.org/10.2147/TCRM.S1458
  10. Muszbek N, Brixner D, Benedict A, Keskinaslan A, Khan ZM. The economic consequences of noncompliance in cardiovascular disease and related conditions: a literature review. Int J Clin Pract 2008;62:338-51. https://doi.org/10.1111/j.1742-1241.2007.01683.x
  11. Kang HY, Yang KH, Kim YN, et al. Incidence and mortality of hip fracture among the elderly population in South Korea: a population-based study using the national health insurance claims data. BMC Public Health 2010;10:230. https://doi.org/10.1186/1471-2458-10-230
  12. Oh IH, Yoon SJ, Seo HY, Kim EJ, Kim YA. The economic burden of musculoskeletal disease in Korea: a cross sectional study. BMC Musculoskelet Disord 2011;12:157. https://doi.org/10.1186/1471-2474-12-157
  13. Sokol MC, McGuigan KA, Verbrugge RR, Epstein RS. Impact of medication adherence on hospitalization risk and healthcare cost. Med Care 2005;43:521-30. https://doi.org/10.1097/01.mlr.0000163641.86870.af
  14. Skaer TL, Sclar DA, Robison LM, Markowski DJ, Won JK. Effect of pharmaceutical formulation for diltiazem on health care expenditures for hypertension. Clin Ther 1993;15:905-11.
  15. Washington DL, Harada ND, Villa VM, et al. Racial variations in Department of Veterans Affairs ambulatory care use and unmet health care needs. Mil Med 2002;167:235-41. https://doi.org/10.1093/milmed/167.3.235
  16. Hodgson TA, Cai L. Medical care expenditures for hypertension, its complications, and its comorbidities. Med Care 2001;39:599-615. https://doi.org/10.1097/00005650-200106000-00008
  17. Friedman O, McAlister FA, Yun L, Campbell NR, Tu K; Canadian Hypertension Education Program Outcomes Research Taskforce. Antihypertensive drug persistence and compliance among newly treated elderly hypertensives in Ontario. Am J Med 2010;123:173-81. https://doi.org/10.1016/j.amjmed.2009.08.008
  18. Lee CY, Huang CC, Shih HC, Huang KH. Factors influencing antihypertensive medication compliance in Taiwan: a nationwide population-based study. Eur J Prev Cardiol 2013;20:930-7. https://doi.org/10.1177/2047487312451252
  19. Lee DH, Choi YH, Lee KH, et al. Factors associated with hypertension control and antihypertensive medication among hypertensive patients in a community. Korean J Prev Med 2003;36:289-97.
  20. Ren XS, Kazis LE, Lee A, Zhang H, Miller DR. Identifying patient and physician characteristics that affect compliance with antihypertensive medications. J Clin Pharm Ther 2002;27:47-56. https://doi.org/10.1046/j.1365-2710.2002.00387.x
  21. Patel RP, Taylor SD. Factors affecting medication adherence in hypertensive patients. Ann Pharmacother 2002;36:40-5. https://doi.org/10.1345/aph.1A046
  22. Sax PE, Meyers JL, Mugavero M, Davis KL. Adherence to antiretroviral treatment and correlation with risk of hospitalization among commercially insured HIV patients in the United States. PLoS One 2012;7:e31591. https://doi.org/10.1371/journal.pone.0031591
  23. Knight EL, Bohn RL, Wang PS, Glynn RJ, Mogun H, Avorn J. Predictors of uncontrolled hypertension in ambulatory patients. Hypertension 2001;38:809-14. https://doi.org/10.1161/hy0901.091681
  24. Ruger JP, Kim HJ. Out-of-pocket healthcare spending by the poor and chronically ill in the Republic of Korea. Am J Public Health 2007;97:804-11. https://doi.org/10.2105/AJPH.2005.080184
  25. Briesacher BA, Gurwitz JH, Soumerai SB. Patients at-risk for cost-related medication nonadherence: a review of the literature. J Gen Intern Med 2007;22:864-71. https://doi.org/10.1007/s11606-007-0180-x
  26. Wald DS, Law M, Morris JK, Bestwick JP, Wald NJ. Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials. Am J Med 2009;122:290-300. https://doi.org/10.1016/j.amjmed.2008.09.038
  27. Dragomir A, Cote R, Roy L, et al. Impact of adherence to antihypertensive agents on clinical outcomes and hospitalization costs. Med Care 2010;48:418-25. https://doi.org/10.1097/MLR.0b013e3181d567bd
  28. Ademi Z, Huq MM, Liew D, et al. The impact of lost therapeutic benefit (LTB) in high-risk hypertensive patients: 2-year follow-up data from the Australian REACH registry. Cardiovasc Ther 2013;31:370-6. https://doi.org/10.1111/1755-5922.12034

피인용 문헌

  1. Improving the Quality of Hypertension Management: Multifaceted Approach vol.49, pp.6, 2019, https://doi.org/10.4070/kcj.2019.0055
  2. Gender Differences in the Risk of Ischemic Heart Disease According to Healthcare Utilization and Medication Adherence among Newly Treated Korean Hypertensive Patients vol.18, pp.3, 2016, https://doi.org/10.3390/ijerph18031274
  3. Clinical impact of guideline-based practice and patients’ adherence in uncontrolled hypertension vol.27, pp.1, 2016, https://doi.org/10.1186/s40885-021-00183-1