Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Modification of nutrition strategy for improvement of postnatal growth in very low birth weight infants

  • Choi, Ah Young (Department of Pediatrics, Chungnam National University Hospital, Chungnam National University School of Medicine) ;
  • Lee, Yong Wook (Department of Pediatrics, Chungnam National University Hospital, Chungnam National University School of Medicine) ;
  • Chang, Mea-young (Department of Pediatrics, Chungnam National University Hospital, Chungnam National University School of Medicine)
  • 투고 : 2015.09.14
  • 심사 : 2015.11.05
  • 발행 : 2016.04.15
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초록

Purpose: To identify the effects of modified parenteral nutrition (PN) and enteral nutrition (EN) regimens on the growth of very low birth weight (VLBW) infants. Methods: The study included VLBW infants weighing <1,500 g, admitted to Chungnam National University Hospital between October 2010 and April 2014, who were alive at the time of discharge. Subjects were divided according to 3 periods: period 1 (n=37); prior to the PN and EN regimen being modified, period 2 (n=50); following the PN-only regimen modification, period 3 (n=37); following both PN and EN regimen modification. The modified PN regimen provided 3 g/kg/day of protein and 1 g/kg/day of lipid on the first day of life. The modified EN regimen provided 3.5-4.5 g/kg/day of protein and 150 kcal/kg/day of energy. We investigated growth rate, anthropometric measurements at 40 weeks postconceptional age (PCA) and the incidence of extrauterine growth restriction (EUGR) at 40 weeks PCA. Results: Across the 3 periods, clinical characteristics, including gestational age, anthropometric measurements at birth, multiple births, sex, Apgar score, surfactant use and PDA treatment, were similar. Growth rates for weight and height, from time of full enteral feeding to 40 weeks PCA, were higher in period 3. Anthropometric measurements at 40 weeks PCA were greatest in period 3. Incidence of weight, height and head circumference EUGR at 40 weeks PCA decreased in period 3. Conclusion: Beginning PN earlier, with a greater supply of protein and energy during PN and EN, is advantageous for postnatal growth in VLBW infants.

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참고문헌

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피인용 문헌

  1. ExtraUterine Growth Restriction (EUGR) in Preterm Infants: Growth Patterns, Nutrition, and Epigenetic Markers. A Pilot Study vol.6, pp.None, 2018, https://doi.org/10.3389/fped.2018.00408
  2. Clinical and Nutritional Determinants of Extrauterine Growth Restriction Among Very Low Birth Weight Infants vol.13, pp.None, 2016, https://doi.org/10.2147/ijgm.s284943
  3. Analysis of Amino Acid Patterns With Nutrition Regimens in Preterm Infants With Extrauterine Growth Retardation vol.8, pp.None, 2016, https://doi.org/10.3389/fped.2020.00184
  4. Delayed initiation of enteral feeds is associated with postnatal growth failure among preterm infants managed at a rural hospital in Uganda vol.20, pp.1, 2016, https://doi.org/10.1186/s12887-020-1986-5
  5. Nutrition, epigenetic markers and growth in preterm infants vol.34, pp.23, 2016, https://doi.org/10.1080/14767058.2019.1702952