Journal of Nutrition and Health

  • 제49권4호
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  • Pages.223-232
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  • 2016
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  • 2288-3886(pISSN)
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  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
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Validation of G-protein beta-3 subunit gene C825T polymorphism as predictor of obesogenic epidemics in overweight/obese Korean children

  • Lee, Yunkyoung (Department of Food Science and Nutrition, Jeju National University) ;
  • Park, Seong-min (Imported Food Analysis Team, Ministry of Food Drug Safety, Gyeongin Regional, Food & Drug Administration) ;
  • Lee, Myoungsook (Department of Food and Nutrition and Research Institute of Obesity Sciences, Sungshin Women's university)
  • 투고 : 2016.06.17
  • 심사 : 2016.07.05
  • 발행 : 2016.08.31
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초록

Purpose: We investigated the potential interaction between the G-protein beta-3 subunit gene (GNB3) C825T polymorphism, a risk factor for chronic disease in various ethnicities, and obesogenic environments in overweight/obese Korean children. Methods: The present study was conducted as a cross-sectional study using measures of anthropometry, blood pressure (BP), and fasting blood samples as well as 3-day food records. Subjects were recruited from seven elementary schools in an urban district in Seoul, South Korea, between 2007 and 2008. A total of 1,260 children aged 8-9 years were recruited in the study, including 633 boys (50.3%) and 627 girls (49.7%). Results: The allele frequencies of the GNB3 polymorphism were C allele = 49.7% and T allele = 50.3% in subjects. In general, boys with T allele had higher BMI, systolic BP (SBP), and triglycerides, although their energy intake was not significantly different from boys with C allele. In contrast to boys, girls with T allele had lower BMI but higher SBP and energy intake than those with C allele. The girls with T allele had a significantly lower BMI and waist circumference in both the normal weight group and obese group (OB). T allele carriers in both genders had significantly higher TC than C allele carriers in the OB group. At last, girls with T allele in OB appeared to have significantly lower HOMA-IR than those with C allele. Conclusion: Unlike higher risk for negative health outcomes by the GNB3 polymorphism in various ethnicities, GNB3 polymorphism did not influence obesogenic environments in overweight/obese Korean children.

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피인용 문헌

  1. Salt-sensitive genes and their relation to obesity vol.50, pp.3, 2017, https://doi.org/10.4163/jnh.2017.50.3.217