Journal of Marine Life Science (한국해양생명과학회지)

The Korean Society of Marine Life Science (한국해양생명과학회)
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Expression of Maturation-Related Genes and Leptin during Sexual Maturation in the Female Goldfish: Effects of Exogenous Kisspeptin

  • Kim, Na Na (Division of Marine BioScience, Korea Maritime and Ocean University) ;
  • Choi, Young Jae (Division of Marine BioScience, Korea Maritime and Ocean University) ;
  • Oh, Sung-Yong (Ecosystem and Biological Research Center, Korea Institute Ocean Science & Technology) ;
  • Choi, Cheol Young (Division of Marine BioScience, Korea Maritime and Ocean University)
  • Received : 2016.04.01
  • Accepted : 2016.04.22
  • Published : 2016.04.30
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Abstract

Kisspeptin (Kiss) and its cognate receptor, kisspeptin receptor (KissR; G protein coupled receptor 54, GPR54), have recently been recognized as potent regulators of reproduction in teleosts. Additionally, leptin plays an important role in energy homeostasis and reproductive function in teleosts. The purpose of this study was to examine differences in the concentration of the hormones of the Kiss/KissR system and leptin and the expression of their underlying genes, all of which are involved in the sexual maturation of female goldfish, Carassius auratus, following treatment with Kiss. The expression levels of KissR increased after the Kiss injection. Furthermore, the peptide hormone leptin also increased after the injection (in vivo and in vitro). Additionally, the expression of GnRH and GTHs (GTHα, FSHβ, and LHβ) increased in the brain and pituitary (in vitro and in vitro). These results support the hypothesis that Kiss plays important roles in the direct regulation of the hypothalamus-pituitary-gonad axis and leptin in goldfish. Therefore, we suggest that Kiss system gene expression is correlated with energy balance and reproduction.

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Acknowledgement

This research was supported by the project titled 'Innovative marine production technology driven by LED-ICT convergence photo-biology', and by Korea Institute of Ocean Science and Technology (PN66370).