Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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A Pair of Oviduct-Born Pickpocket Neurons Important for Egg-Laying in Drosophila melanogaster

  • Lee, Hyunjin (School of Life Sciences, Gwangju Institute of Science and Technology) ;
  • Choi, Hyun Woo (School of Life Sciences, Gwangju Institute of Science and Technology) ;
  • Zhang, Chen (School of Life Sciences, Gwangju Institute of Science and Technology) ;
  • Park, Zee-Yong (School of Life Sciences, Gwangju Institute of Science and Technology) ;
  • Kim, Young-Joon (School of Life Sciences, Gwangju Institute of Science and Technology)
  • Received : 2016.05.10
  • Accepted : 2016.05.25
  • Published : 2016.07.31
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Abstract

During copulation, male Drosophila transfers Sex Peptide (SP) to females where it acts on internal sensory neurons expressing pickpocket (ppk). These neurons induce a post-mating response (PMR) that includes elevated egg-laying and refractoriness to re-mating. Exactly how ppk neurons regulate the different aspects of the PMR, however, remains unclear. Here, we identify a small subset of the ppk neurons which requires expression of a pre-mRNA splicing factor CG3542 for egg-laying, but not refractoriness to mating. We identify two CG3542-ppk expressing neurons that innervate the upper oviduct and appear to be responsible for normal egg-laying. Our results suggest specific subsets of the ppk neurons are responsible for each PMR component.

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