Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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The Role of Lymphatic Niches in T Cell Differentiation

  • Capece, Tara (Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester) ;
  • Kim, Minsoo (Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester)
  • Received : 2016.04.05
  • Accepted : 2016.05.24
  • Published : 2016.07.31
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Abstract

Long-term immunity to many viral and bacterial pathogens requires$ CD8^+$ memory T cell development, and the induction of long-lasting$ CD8^+$ memory T cells from a $na{\ddot{i}}ve$, undifferentiated state is a major goal of vaccine design. Formation of the memory$ CD8^+$ T cell compartment is highly dependent on the early activation cues received by $na{\ddot{i}ve}$ $CD8^+$ T cells during primary infection. This review aims to highlight the cellularity of various niches within the lymph node and emphasize recent evidence suggesting that distinct types of T cell activation and differentiation occur within different immune contexts in lymphoid organs.

Keywords

References

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