Journal of the Korean Society of Radiology (한국방사선학회논문지)

The Korean Society of Radiology (한국방사선학회)
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The Effect of Lipid Peroxidation of White Ginseng(WG) and Fermented Ginseng(FG) Extracts on the Liver of Mice by R-ray Irradiation

감마선을 조사한 생쥐 간에서 발효인삼이 지질과산화에 미치는 영향

  • Ko, In-Ho (Dept. of Radiological Technology, Cheju Halla University) ;
  • Yeo, Jin-Dong (Dept. of Radiological Technology, Sarabol University)
  • 고인호 (제주한라대학교 방사선과) ;
  • 여진동 (서라벌대학교 방사선과)
  • Received : 2016.03.21
  • Accepted : 2016.06.30
  • Published : 2016.06.30
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Abstract

The effects of White Ginseng and Fermented Ginseng on liver damage induced by $^{60}Co$ r-ray irradiation were investigated. To one group of ICR male mice were given in White Ginseng(150 mg/kg/day for 7days, orally) before 5Gy(1.01Gy/min) dose of $^{60}Co$ r-ray irradiation. To another group were given in Fermented Ginseng (150 mg/kg/day for 7days, orally)before 5Gy(1.01Gy/min)dose of $^{60}Co$ r-ray irradiation was investigated. Radiation irradiation group were given with saline(0.1 ml) and 5Gy. Contrast group were given with saline(0.1 ml). The levels of $H_2O_2$, catalase and MDA in liver tissue were measured. In Fermented Ginseng (FG+Rad) group and white Ginseng(WG+Rad) group than irradiation group(Rad), the catalase level were significantly increased, and the catalase levels were appeaWhite at radiation protection. It was significantly decreased to MDA and $H_2O_2$ level to Fermented Ginseng (FG+Rad) group and white Ginseng(WG+Rad) group than irradiation group(Rad). Therefore, Fermented Ginseng and white Ginseng were very excellent protector on radiation of liver in mice.

방사선에 의해서 유도된 간 손상에 대한 백삼과 발효인삼추출물의 보호효과를 비교 연구하였다. ICR계 생쥐에게 코발트-60 감마선의 5Gy조사 7일 전부터 백삼과 발효인삼추출물(150mg/kg/day)을 각각 투여하였다. 대조군은 생리적 식염수를 투여하고 방사선조사군은 생리적 식염수를 투여하면서 5Gy를 조사하였다. 그리고 각각의 실험군에서 간조직의 $H_2O_2$, catalase, MDA를 측정하였다. 그 결과 방사선조사군과 보다 백삼과 발효인삼추출물 투여군에서 catalase함량이 유의성 있게 증가하여 간의 보호효과가 있었으며 $H_2O_2$와 MDA함량도 유의성 있게 감소하였다. 백삼과 발효인삼이 간 조직에 대한 방사선조사로 부터 매우 우수한 방호제라고 할 수가 있다.

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References

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