DOI QR코드

DOI QR Code

Arrhythmogenic Right Ventricular Cardiomyopathy in a Cat with Hepatic Lipidosis

  • Nam, Aryung (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Park, Hyung-Jin (College of Veterinary Medicine, Chungnam National University) ;
  • Kim, Jun-Seok (College of Veterinary Medicine, Chungnam National University) ;
  • Song, Kun-Ho (College of Veterinary Medicine, Chungnam National University) ;
  • Youn, Hwa-Young (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University) ;
  • Seo, Kyoung-Won (College of Veterinary Medicine, Chungnam National University)
  • 투고 : 2016.04.04
  • 심사 : 2016.05.17
  • 발행 : 2016.06.30

초록

A Turkish angora cat with a one-week history of anorexia and vomiting was diagnosed with hepatic lipidosis. During hospitalization and treatment, the cat suddenly showed respiratory-related clinical signs, including coughing and dyspnea, 13 days after initial diagnosis. Due to the poor response to treatment, the patient was euthanized at the owner's request. A postmortem histopathologic examination of the cat's heart showed dilation and wall thinning of the right atrium and ventricle, with fibrofatty infiltration corresponding to an arrhythmogenic right ventricular cardiomyopathy (ARVC). This is a case report of ARVC concurrent with hepatic lipidosis in a cat; both diseases are related to disturbances in lipid metabolism.

키워드

참고문헌

  1. Basso C, Corrado D, Marcus FI, Nava A, Thiene G. Arrhythmogenic right ventricular cardiomyopathy. The Lancet 2009; 373: 1289-1300. https://doi.org/10.1016/S0140-6736(09)60256-7
  2. Castanos Gutierrez SL, Kamel IR, Zimmerman SL. Current concepts on diagnosis and prognosis of arrhythmogenic right ventricular cardiomyopathy/ dysplasia. J Thorac Imaging 2015.
  3. Center SA. Feline hepatic lipidosis. Vet Clin North Am Small Anim Pract 2005; 35: 225-269. https://doi.org/10.1016/j.cvsm.2004.10.002
  4. Corrado D, Basso C, Thiene G. Arrhythmogenic right ventricular cardiomyopathy: diagnosis, prognosis, and treatment. Heart 2000; 83: 588-595. https://doi.org/10.1136/heart.83.5.588
  5. Desvergne B, Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 1999; 20: 649-688.
  6. Dimski DS, Joseph T. Feline idiopathic hepatic lipidosis. Vet Clin North Am Small Anim Pract 1995; 25: 357-373. https://doi.org/10.1016/S0195-5616(95)50031-2
  7. Djouadi F, Lecarpentier Y, Hebert J-L, Charron P, Bastin J, Coirault C. A potential link between peroxisome proliferatoractivated receptor signaling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy. Cardiovasc Res 2009; 84: 83-90. https://doi.org/10.1093/cvr/cvp183
  8. Fornes P, Ratel S, Lecomte D. Pathology of arrhythmogenic right ventricular cardiomyopathy/dysplasia--an autopsy study of 20 forensic cases. J Forensic Sci 1998; 43: 777-783.
  9. Fox PR, Maron BJ, Basso C, Liu S-K, Thiene G. Spontaneously occurring arrhythmogenic right ventricular cardiomyopathy in the domestic cat a new animal model similar to the human disease. Circulation 2000; 102: 1863-1870. https://doi.org/10.1161/01.CIR.102.15.1863
  10. Fox PR, Liu S-K, Maron BJ, Echocardiographic assessment of spontaneously occurring feline hypertrophic cardiomyopathy. An animal model of human disease. Circulation 1995; 92: 2645-2651. https://doi.org/10.1161/01.CIR.92.9.2645
  11. Gemayel, C, Pelliccia, A and Thompson, P1D 2001 Arrhythmogenic right ventricular cardiomyopathy J Am Coll Cardiol 38, 1773-1781.
  12. Gerull B, A Heuser, T Wichter, M Paul, CT Basson, DA McDermott, BB Lerman, SM Markowitz, PT Ellinor, CA MacRae, S Peters, KS Grossmann, B Michely, S Sasse-Klaassen, W Birchmeier, R Dietz, G Breithardt, E Schulze-Bahr, L Thierfelder. Mutations in the desmosomal protein plakophilin-2 are common in arrhythmogenic right ventricular cardiomyopathy. Nat Genet 2004; 36: 1162-1164. https://doi.org/10.1038/ng1461
  13. Harvey A, Battersby I, Faena M, Fews D, Darke P, Ferasin L. Arrhythmogenic right ventricular cardiomyopathy in two cats. J Small Anim Pract 2005; 46: 151-156. https://doi.org/10.1111/j.1748-5827.2005.tb00306.x
  14. Iyer VR, AJ Chin. Arrhythmogenic right ventricular cardiomyopathy/Dysplasia (ARVC/D). Am J Med Genet C Semin Med Genet 2013; 163: 185-197. https://doi.org/10.1002/ajmg.c.31368
  15. Kies P, Bootsma M, Bax J, Schalij MJ, van der Wall EE. Arrhythmogenic right ventricular dysplasia/cardiomyopathy: screening, diagnosis, and treatment. Heart Rhythm 2006; 3: 225-234. https://doi.org/10.1016/j.hrthm.2005.10.018
  16. Knafo SE, Rapoport G, Williams J, Brainard B, Driskell E, Uhl E, Crochik S, Divers SJ. Cardiomyopathy and rightsided congestive heart failure in a red-tailed hawk (Buteo jamaicensis). J Avian Med Surg 2011; 25: 32-39. https://doi.org/10.1647/2009-057.1
  17. Liu S-K, WC Roberts, BJ Maron, Comparison of morphologic findings in spontaneously occurring hypertrophic cardiomyopathy in humans, cats and dogs. Am J Cardiol 1993; 72: 944-951. https://doi.org/10.1016/0002-9149(93)91112-U
  18. Marcus FI, WJ McKenna, D Sherrill, C Basso, B Bauce, DA Bluemke, H Calkins, D Corrado, MGPJ Cox, JP Daubert, G Fontaine, K Gear, R Hauer, A Nava, MH Picard, N Protonotarios, JE Saffitz, DMY Sanborn, JS Steinberg, H Tandri, G Thiene, JA Towbin, A Tsatsopoulou, T Wichter, W Zareba. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria. Circulation 2010; 121: 1533-1541. https://doi.org/10.1161/CIRCULATIONAHA.108.840827
  19. McKenna WJ, G Thiene, A Nava, F Fontaliran, C Blomstrom- Lundqvist, G Fontaine, F Camerini. Diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy task force of the working group myocardial and pericardial disease of the european society of cardiology and of the scientific council on cardiomyopathies of the international society and federation of cardiology. Br heart J 1994; 71: 215-218. https://doi.org/10.1136/hrt.71.3.215
  20. Meurs KM, Spier AW, Miller MW, Lehmkuhl L, Towbin JA. Familial ventricular arrhythmias in boxers. J Vet Intern Med 1999; 13: 437-439. https://doi.org/10.1111/j.1939-1676.1999.tb01460.x
  21. Nava A, Thiene G, Canciani B, Scognamiglio R, Daliento L, Buja G, Martini B, Stritoni P, Fasoli G. Familial occurrence of right ventricular dysplasia: A study involving nine families. J Am Coll Cardiol 1988; 12: 1222-1228. https://doi.org/10.1016/0735-1097(88)92603-4
  22. PALACIO MFD, Bernal LJ, Bayon A, Bernabe A, OCA R, Seva J. Arrhythmogenic right ventricular dysplasia/cardiomyopathy in a Siberian husky. J Small Anim Pract 2001; 42: 137-142. https://doi.org/10.1111/j.1748-5827.2001.tb02010.x
  23. Sen-Chowdhry S, RD Morgan, JC Chambers, WJ McKenna. Arrhythmogenic cardiomyopathy: etiology, diagnosis, and treatment. Annual Review of Med 2010; 61: 233-253. https://doi.org/10.1146/annurev.med.052208.130419
  24. Simpson KW, Bonagura JD, Eaton KA. Right ventricular cardiomyopathy in a dog. J Vet Intern Med 1994; 8: 306-309. https://doi.org/10.1111/j.1939-1676.1994.tb03240.x