Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Relievable Effect of Alpinetin on Dexamethasone-Induced Skin Aging

Alpinetin의 Dexamethasone으로 유도한 피부 노화 완화 효과

  • Received : 2016.02.16
  • Accepted : 2016.06.24
  • Published : 2016.06.30
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Abstract

Steroid hormone, glucocorticoid (GC) has strong anti-inflammatory effects by binding to glucocorticoid receptor (GR) inhibiting the expression of inflammatory genes. Therefore, agents that activate the GR have been used for the treatment of dermatitis. However, the agents have side effects such as skin barrier dysfunction and dermal atrophy, inducing skin damage as well as skin aging. It has been reported that GC is activated by 11 beta-hydroxysteroid dehydrogenase type 1 ($11{\beta}$-HSD1) to increase the activity of the GR. This study aimed to identify natural materials that can effectively inhibit dexamethasone. We found that alpinetin isolated from Alpinia katsumadai extract has a significant effect on this. Alpinetin not only inhibited $11{\beta}$-HSD1 expression, but also suppressed the increase of phosphorylated GR and cortisol concentration. Alpinetin also recovered collagen expression in dexamethasone-treated dermal fibroblasts, and the reduction of dermal thickness in dexamethasnone-treated 3D skin model. These results suggest that alpinetin prevents skin aging induced by the increase of $11{\beta}$-HSD1 expression.

스테로이드 호르몬인 glucocorticoid (GC)는 glucocorticoid receptor (GR)와 결합하여 염증 유전자의 발현을 억제함으로써 강력한 항염 효과를 준다. 따라서 GR을 활성화하는 GC 제제들이 개발되어 피부염의 치료제로 사용되어 왔다. 그러나 이러한 GC 제제들은 피부 장벽 기능 저하, 진피층 두께 감소 등의 부작용을 유발하여 피부를 손상시키고 피부 노화를 유발한다. 특히 GC 성분은 11 beta-hydroxysteroid dehydrogenase type 1 ($11{\beta}$-HSD1)에 의해 활성화되어 GR의 활성을 높이는 것으로 보고되어 있다. 이에 본 연구에서는 스테로이드 제제인 dexamethasone에 의해 증가된 $11{\beta}$-HSD1의 발현을 효과적으로 억제할 수 있는 천연 소재를 발굴하고자 하여, 초두구 추출물에서 유래한 alpinetin에서 유의한 효과가 있음을 확인하였다. Alpinetin은 진피 섬유아세포에서 dexamethasone에 의해 발현이 증가한 $11{\beta}$-HSD1를 억제함과 동시에 GR의 활성 및 cortisol의 생성을 감소시켰다. 또한 사람 섬유아세포 및 3D skin model을 이용한 평가에서, alpinetin은 dexamethasone에 의한 콜라겐 감소와 진피층 두께 감소를 효과적으로 회복시켰다. 따라서, 본 연구 결과로부터 alpinetin은 $11{\beta}$-HSD1의 발현 증가에 의한 피부 스트레스 및 피부 노화를 효과적으로 예방할 수 있을 것으로 사료되었다.

Keywords

References

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