YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Study on Lifespan Extension Effect of Leonurine and its Synthetic Fragmental Analogs on Caenorhabditis elegans

예쁜꼬마선충을 이용한 레오누린과 그 합성 분절 유도체의 수명연장 효과 연구

  • Received : 2016.04.19
  • Accepted : 2016.05.24
  • Published : 2016.06.30
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Abstract

The current study was conducted to evaluate the lifespan extension effects of leonurine and its synthetic fragmental analogs using Caenohabditis elegans model system. Leonurine significantly prolonged the lifespan of C. elegans in a dose-dependent manner. To dissect the structure-activity relationship between leonurine and lifespan extension activity, seven novel fragmental analogs were synthesized and evaluated. Our study revealed that benzoate part of leonurine is responsible for its lifespan extension property rather than quanidine moiety.

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References

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