YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Inhibitory Activities of 1,5-Diarylimidazole Derivatives with Methylthiophenyl Group against PGE2 Production

메틸싸이오페닐기 함유 1,5-다이아릴 이미다졸 유도체의 프로스타글란딘 생성 억제작용

  • Kwon, Jae-Hyun (School of Medicine, Kangwon National University) ;
  • Park, Haeil (College of Pharmacy, Kangwon National University) ;
  • Kim, Sung-Soo (School of Medicine, Kangwon National University)
  • 권재현 (강원대학교 의학전문대학원) ;
  • 박해일 (강원대학교 약학대학) ;
  • 김성수 (강원대학교 의학전문대학원)
  • Received : 2016.02.26
  • Accepted : 2016.04.01
  • Published : 2016.06.30
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Abstract

Inhibitory activities of 1,5-diarylimidazole analogs with methylthiophenyl group on prostaglandin $E_2$ ($PGE_2$) production from LPS-treated RAW 264.7 cells, were evaluated and compared with those of the corresponding analogs with 4-methanesulfonylphenyl group. Among the tested nineteen analogs with methylthiophenyl group, fourteen analogs showed strong inhibitory activities (>88%) when compared with the reference compound NS-398, and fifteen analogs have similar inhibitory activities with those of parent analogs with 4-methanesulfonylphenyl group. Those results suggest that most of 1,5-diarylimidazole analogs with methanesulfonylphenyl group can be also active even after they are metabolized by reduction.

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References

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