Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Phenolic Constituents and Their Anti-inflammatory Activity from Echinochloa utilis Grains

  • Nguyen, Duc Hung (College of Pharmacy, Catholic University of Daegu) ;
  • Zhao, Bing Tian (College of Pharmacy, Catholic University of Daegu) ;
  • Le, Duc Dat (College of Pharmacy, Catholic University of Daegu) ;
  • Kim, Ki Yun (Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University) ;
  • Kim, Young Ho (Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungpook National University) ;
  • Yoon, Young Ho (Functional Cereal Crop research Division, Department of Functional Crop, NICS, RDA) ;
  • Ko, Jee Youn (Functional Cereal Crop research Division, Department of Functional Crop, NICS, RDA) ;
  • Woo, Koan Sik (Functional Cereal Crop research Division, Department of Functional Crop, NICS, RDA) ;
  • Woo, Mi Hee (College of Pharmacy, Catholic University of Daegu)
  • Received : 2015.12.08
  • Accepted : 2016.02.04
  • Published : 2016.06.30
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Abstract

Seven phenolic compounds including p-coumaric acid (1), 4-hydroxybenzoic acid (2), 4-hydroxybenzaldehyde (3), vanillic acid (4), luteolin (5), acacetin (6), and tricin (7), were isolated from the methylene chloride and ethyl acetate fractions of Echinochloa utilis grains. Compounds (1 - 4, 6) were isolated for the first time from this plant. These compounds were tested for inhibitory activities against LPS-induced NO production in RAW 264.7 cells. Compounds 5 and 6 displayed significant inhibitory effects, with $IC_{50}$ values of $27.9{\pm}2.6$ and $14.0{\pm}1.1{\mu}M$, respectively. The results suggested that E. utilis ethanolic extract may be used as a potential source of anti-inflammatory agents and functional foods for the treatment of allergic diseases.

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