Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Compounds from a jellyfish-derived fungus Aspergillus fumigates

  • Tao, Guan-yu (Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences) ;
  • Liu, Juan (Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences) ;
  • Jung, Jee H. (College of Pharmacy, Pusan National University) ;
  • Guo, Wei (School of Traditional Chinese Medicine, Southern Medical University) ;
  • Wen, Xiao-qiong (School of Traditional Chinese Medicine, Southern Medical University) ;
  • Liu, Yonghong (Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences)
  • Received : 2015.08.06
  • Accepted : 2015.10.22
  • Published : 2016.06.30
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Abstract

Six compounds were isolated from the secondary metabolites of the jellyfish-derived fungus Aspergillus fumigates, whose structures were identified by chemical methods and spectroscopic analysis as pseurotin F1 (1), azaspirofurans B (2), $(22E,\;24R)-24-methyl-5{\alpha}-cholesta-7,22-diene-3{\beta},5,6{\beta}-triol$ (3), $5{\alpha},8{\alpha}-epidioxyergosta-6,22-dien-3{\beta}-o1$ (4), $cyclo-({\small{L}}-Pro-{\small{L}}-Tyr)$ (5), fumitremorgin C (6). The compounds 1 - 5 were isolated from the fungus Aspergillus fumigates for the first time. The isolated compounds (1 - 6) were evaluated for antibiotic activity and cytotoxicity against six bacterial strains and ten human tumor cell lines, respectively.

Keywords

References

  1. Mille-Lindblom, C.; Fischer, H.; Tranvik, L. J. OIKOS. 2006, 113, 233-242. https://doi.org/10.1111/j.2006.0030-1299.14337.x
  2. Zhang, H. W.; Song, Y. C.; Tan, R. X. Nat. Prod. Rep. 2006, 23, 753-771. https://doi.org/10.1039/b609472b
  3. Blunt, J. W.; Copp, B. R.; Keyzers, R. A. Munro, M. H.; Prinsep, M. R. Nat. Prod. Rep. 2014, 31, 160-258. https://doi.org/10.1039/c3np70117d
  4. Uye, S. Plankton Benthos Res. 2008, 3, 125-131. https://doi.org/10.3800/pbr.3.125
  5. Wink, J.; Grabley, S.; Gareis, M.; Thiericke, R.; Kirsch, R. European Patent Application 1993, EP0546474A1.
  6. Frisvad, J. C.; Rank, C.; Nielsen, K. F. Med. Mycol. 2009, 47, S53-S71. https://doi.org/10.1080/13693780802307720
  7. Wenke, J.; Anke, H.; Sterner, O. Biosci. Biotech. Biochem. 1993, 57, 961-964. https://doi.org/10.1271/bbb.57.961
  8. Ren, H.; Liu, R.; Chen, L. Zhu, T.; Zhu, W. M.; Gu, Q. Q. Arch. Pharm. Res. 2010, 33, 499-502. https://doi.org/10.1007/s12272-010-0401-4
  9. Mohr, P.; Tamm, C. Tetrahedron 1981, 37, 201-212. https://doi.org/10.1016/0040-4020(81)85056-9
  10. Mohr, P.; Tamm, C. Tetrahedron Lett. 1987, 28, 391-394 https://doi.org/10.1016/S0040-4039(00)95736-8
  11. Tsunematsu, Y.; Fukutomi, M.; Saruwatari, T. Noguchi, H.; Hotta, K.; Tang, Y.; Watanabe, K. Angew. Chem. Int. Ed. Engl. 2014, 53, 8475-8479. https://doi.org/10.1002/anie.201404804
  12. Vincenzo, P.; Donato, S. J. Nat. Prod. 1987, 50, 915-920. https://doi.org/10.1021/np50053a024
  13. Wang, X.; Wang, H.; Liu, T.; Xin Z. Appl. Microbiol. Biotechnol. 2014, 98, 4875-4885. https://doi.org/10.1007/s00253-014-5572-3
  14. Ioannou, E.; Abdel-Razik, A. F.; Zervou, M.; Christofidis, D.; Alexi, X.; Vagias, C.; Alexis, M. N.; Roussis, V. Steroids 2009, 74, 73-80. https://doi.org/10.1016/j.steroids.2008.09.007
  15. Gauvin, A.; Smadja, J.; Aknin, M. Can. J. Chem. 2000, 78, 986-992.
  16. Bu, M.; Yang, B. B.; Hu, L. Med. Chem. 2014, 4, 709-716.
  17. Jayatilake, G. S.; Thornton, M. P.; Leonard, A. C. J. Nat. Prod. 1996, 59, 293-296. https://doi.org/10.1021/np960095b
  18. Cimmino, A.; Puopolo, G.; Perazzolli, M.; Andolfi, A.; Melck, D.; Pertot, I.; Evidente, A. Chem. Heterocycl. Compds. 2014, 50, 290-295. https://doi.org/10.1007/s10593-014-1475-6
  19. Borthwick, A. D. Chem. Rev. 2012, 112, 3641-3716. https://doi.org/10.1021/cr200398y
  20. Zhang, D.; Noviendri, D.; Nursid, M.; Yang, X.; Son, B. W. Nat. Prod. Sci. 2007, 13, 251-254.
  21. Puopolo, G.; Cimmino, A.; Palmieri, M. C. Giovannini, O.; Evidente, A.; Pertot, I. J. Appl. Microbiol. 2014, 117, 1168-1180. https://doi.org/10.1111/jam.12611

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