Journal of Korean Medicine for Obesity Research (한방비만학회지)

The Society of Korean Medicine for obesity Research (한방비만학회)
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Antiobesity Effect of Water Extract of Coix lacrymajobi var. mayuen in High Fat Fed C5BL/6 Mice

고지방 식이로 비만이 유도된 C5BL/6 마우스에서 의이인 물 추출물의 항비만 효과

  • Song, Mi-Young (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongguk University) ;
  • Jung, Hyo Won (Department of Herbology, College of Korean Medicine, Dongguk University) ;
  • Park, Yong-Ki (Department of Herbology, College of Korean Medicine, Dongguk University)
  • 송미영 (동국대학교 한의과대학 한방재활의학교실) ;
  • 정효원 (동국대학교 한의과대학 본초학교실) ;
  • 박용기 (동국대학교 한의과대학 본초학교실)
  • Received : 2016.05.20
  • Accepted : 2016.06.09
  • Published : 2016.06.30
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Abstract

Objectives: This study investigated the effects of water extract of Coix lacrymajobi var. mayuen on obesity and its associated factors in high fat diet (HFD) induced obese mice. Methods: Male C5BL/6 mice were randomly assigned to 4 groups, normal group (chow diet), a HFD, HFD with water extract of Coix lacrymajobi var. mayuen 100 mg/kg (W-Coix), and HFD with phentermine 5 mg/kg (Phen) as positive control. Body weight, food intake, fasting blood glucose were checked every week and then organs, blood serums were collected after 16 weeks of treatment. Results: Body weight and adipocyte size were significantly lesser in W-Coix than in HFD group; however energy efficiency in W-Coix were not different with HFD. The oral glucose tolerance test, serum glucose and insulin were significantly decreased in W-Coix, also lipid accumulations in liver tissue and lipid levels (total cholesterol, high density lipoprotein-cholesterol) were improved with W-Coix treatment. However skeletal muscle loss with HFD was not changed in W-Coix compared with HFD group. Conclusions: The W-Coix treatment decreased body weight, adipocyte size and it is associated with improved glucose and lipid metabolism. Further studies are needed to know the mechanism of antiobesity in W-Coix.

Keywords

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