Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Evaluation of the cytotoxicity of gold nanoparticle-quercetin complex and its potential as a drug delivery vesicle

  • Pak, Pyo June (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University) ;
  • Go, Eun Byeol (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University) ;
  • Hwang, Min Hee (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University) ;
  • Lee, Dong Gun (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University) ;
  • Cho, Mi Ju (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University) ;
  • Joo, Yong Hoon (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University) ;
  • Chung, Namhyun (Department of Biosystems Engineering, College of Life Sciences and Biotechnology, Korea University)
  • Received : 2016.03.26
  • Accepted : 2016.03.29
  • Published : 2016.06.30
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Abstract

Recently, conjugates of medicinal herb-derived bioflavonoids, such as quercetin, and gold nanoparticles (GNPs) have gained attention as targeted drug delivery systems. In the present study, because quercetin is an important flavonoid with anti-cancer, anti-inflammatory, and anti-oxidant properties, GNP-quercetin complexes (GNPQs) were synthesized to investigate possible adverse effects such as cytotoxicity. We found that while quercetin was cytotoxic, GNPQs were not cytotoxic towards the RAW 264.7 and THP-1 cell lines. Therefore, GNPQs may serve as a potential drug delivery system for cancer treatment.

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References

  1. Harris PE, Cooper KL, Relton C, Thomas KJ (2012) Prevalence of complementary and alternative medicine (CAM) use by the general population: a systematic review and update. Int J Clin Pract 66: 924-939 https://doi.org/10.1111/j.1742-1241.2012.02945.x
  2. Jung HJ, Pak PJ, Park SH, Ju JE, Kim JS, Lee HS, Chung N (2014) Silver wire amplifies the signaling mechanism for IL-1beta production more than silver submicroparticles in human monocytic THP-1 cells. PLoS One 9: e112256 https://doi.org/10.1371/journal.pone.0112256
  3. Kim BI, Joo YH, Pak PJ, Kim JS, Chung N (2015) Different shapes of $Al_2O_3$ particles induce differential cytotoxicity via a mechanism involving lysosomal destabilization and reactive oxygen species generation. J Korean Soc Appl Biol Chem 58: 433-442 https://doi.org/10.1007/s13765-015-0038-6
  4. Kumar A, Zhang X, Liang XJ (2013) Gold nanoparticles: emerging paradigm for targeted drug delivery system. Biotechnol Adv 31: 593-606 https://doi.org/10.1016/j.biotechadv.2012.10.002
  5. Loganayaki N, Siddhuraju P, Manian S (2012) Antioxidant, anti-inflammatory and anti-nociceptive effects of Ammannia baccifera L. (Lythracceae), a folklore medicinal plant. J Ethnopharmacol 140: 230-233 https://doi.org/10.1016/j.jep.2012.01.001
  6. Pal R, Panigrahi S, Bhattacharyya D, Chakraborti AS (2013) Characterization of citrate capped gold nanoparticle-quercetin complex: Experimental and quantum chemical approach. J Mol Struct 1046: 153-163 https://doi.org/10.1016/j.molstruc.2013.04.043
  7. Rubio L, Motilva MJ, Romero MP (2013) Recent advances in biologically active compounds in herbs and spices: a review of the most effective antioxidant and anti-inflammatory active principles. Crit Rev Food Sci Nutr 53: 943-953 https://doi.org/10.1080/10408398.2011.574802
  8. Russo GL, Russo M, Spagnuolo C, Tedesco I, Bilotto S, Iannitti R, Palumbo R (2014) Quercetin: a pleiotropic kinase inhibitor against cancer. Cancer Treat Res 159: 185-205 https://doi.org/10.1007/978-3-642-38007-5_11
  9. Russo M, Spagnuolo C, Tedesco I, Bilotto S, Russo GL (2012) The flavonoid quercetin in disease prevention and therapy: facts and fancies. Biochem Pharmacol 83: 6-15 https://doi.org/10.1016/j.bcp.2011.08.010
  10. Sidhu MC, Sharma T (2013) Medicinal plants from twelve families having antidiabetic activity: a review. Am J PharmTech Res 3: 36-52
  11. Verma HN, Singh P, Chavan RM (2014) Gold nanoparticle: synthesis and characterization. Vet World 7: 72-77 https://doi.org/10.14202/vetworld.2014.72-77
  12. Wang J, Zhou ND, Zhu ZQ, Huang JY, Li GX (2007) Detection of flavonoids and assay for their antioxidant activity based on enlargement of gold nanoparticles. Anal Bioanal Chem 388: 1199-1205 https://doi.org/10.1007/s00216-007-1295-y

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