DOI QR코드

DOI QR Code

A case report on the use of processed Glycyrrhiza uralensis extract and Korean medical treatment for a patient with Amyotrophic Lateral Sclerosis(ALS)

  • Cha, Eun Hye (Department of Acupuncture & Moxibustion Medicine, Wonkwang University Gwangju Korean Medical Hospital) ;
  • Lee, Seong Jin (Department of Acupuncture & Moxibustion Medicine, Wonkwang University Gwangju Korean Medical Hospital) ;
  • Lee, Ji In (Department of Acupuncture & Moxibustion Medicine, Wonkwang University Gwangju Korean Medical Hospital) ;
  • Song, In Ja (Department of Nursing, Gwang-Ju Womens University) ;
  • Kim, Sung Chul (Department of Acupuncture & Moxibustion Medicine, Wonkwang University Gwangju Korean Medical Hospital)
  • Received : 2016.05.11
  • Accepted : 2016.06.03
  • Published : 2016.06.20

Abstract

Objectives : The serum creatine kinase(CK) level of Amyotrophic Lateral Sclerosis(ALS) patients suggests that it may be an independent prognostic factor for the survival of ALS. We report the changes of serum CK level of ALS patients treated by administering processed Glycyrrhiza uralensis extracts and Korean medical treatments. Methods : We provided an ALS patient with processed Glycyrrhiza uralensis extracts and Korean medical treatments including acupuncture, pharmacopuncture and herbal medicine. The serum CK level was checked every month. The changes of ALSFRS-R and MRC grade were checked every month for additional result. Results : The serum CK level as the prognostic factor for the survival of ALS gradually decreased for three months. However, ALSFRS-R decreased by two points at the second trial. MRC rate had no change for three months. Conclusion : Combined administration of processed Glycyrrhiza uralensis extracts and Korean medical treatment could be meaningful possibilities in the treatment of ALS. We should conduct further studies to solve the limitations of this case study.

Keywords

References

  1. C.Carlesi, L. pasquali, S. piazza et al. Strategies for clinical approach of neurodegeneartion in amyotrophic lateral sclerosis. Archives itallenes de bilologie. 2011 ; 149(1) : 151.
  2. Richard W. Orell. Motor neuron disease : systematic reviews of treatment for ALS and SMA. British Medical Bulletin. 2010 ; 93(1) : 145-6. https://doi.org/10.1093/bmb/ldp049
  3. Lacomblex L, Bensimon G, Leigh PN et al. Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study group II. Lancet. 1996 ; 347(9013) : 1425-31. https://doi.org/10.1016/S0140-6736(96)91680-3
  4. Yoon MY, Jun KI, Son ES et al. Induction of Glutathione S-transferase Activity by the Extracts of Glycyrrhiza uralensis Fischer. Appl Biol Chem J. 2008 ; 51(3) : 228-9.
  5. Gibson SB, Kasarskis EJ, Hu N et al. Relationship of creatine kinase to body composition, disease state, and logevity in ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2015 ; 16(7-8) : 473-7.
  6. Ince PG, Lowe J, Shaw PJ. Amyotrophic lateral sclerosis : Current issues in classification, pathogenesis and molecular pathology. Neuropathol Appl Neurobiol. 1998 ; 24(2) : 104-17. https://doi.org/10.1046/j.1365-2990.1998.00108.x
  7. Andersen PM, Abrahams S, Borasio GD et al. EFNS guidelines on the clinical management of amyotrophic lateral sclerosis (MALS)-revised report of an EFNS task force. Eur J Neurol. 2012 ; 19(3) : 360. https://doi.org/10.1111/j.1468-1331.2011.03501.x
  8. Bae JS, Hong YH, Baek W et al. Current status of the diagnosis and management of amyotrophic lateral sclerosis in Korea : A multicenter cross-sectional study. J Clinical Neurol. 2012 ; 8(4) : 293-300. https://doi.org/10.3988/jcn.2012.8.4.293
  9. Data of Electronic Media Morse SS. Wikipedia. Liquorice. Available from : URL : https://en.wikipedia.org/wiki/Liquorice.
  10. D. Wang, T.Q. Guo, Z.Y. Wang et al. ERKs and mitochondria-related pathways are essential for glycyrrhizic acid-mediated neuroprotection against glutamate-induced toxicity in differentiated PC12 cells. Braz J Med Biol Res. 2014 ; 47(9) : 777-8.
  11. Blasco H, Mavel S, Corcia P, Gordon PH. The glutamate hypothesis in ALS : pathophysiology and drug development. Curr Med Chem. 2014 ; 21(31) : 3551. https://doi.org/10.2174/0929867321666140916120118
  12. Jo SG, Im BG, Jo HG et al. Licorice induced hypokalemia. Kidney research and clinical practice. 2001 ; 20(6) : 1021-5.
  13. Park KA, Seok SJ, Kim SJ et al. A Case of licorice-Induced hypokalemic rhabdomyolysis in a patient using a diuretic drug. Korean J Med. 2011 ; 80(2) : 258.
  14. Ahn SG, Lee SR, Yang YS. The treatise research on Hua-Tuo-Jia-Ji-Xue. The Acupuncture. 2000 ; 17(4) : 139.
  15. Lee SM, Yang EJ, Choi SM et al. Effects of Bee Venom on Glutamate-Induced Toxicity in Neuronal and Glial Cells. Evid Based Complement Alternat Med. 2012 ; 2012 : 368196.
  16. Jeon HJ, Nam SS, Kim YS. Neuroprotection of Dopaminergic Neurons by Hominis placenta Herbal Acupuncture in in vitro and in vivo Models of Parkinson's Disease Induced by MPP+/MPTP Toxicity. The Acupuncture. 2015 ; 32(1) : 23-36. https://doi.org/10.13045/acupunct.2015003
  17. Guo L, Cho SY, Kang SS et al. Orthogonal array design for optimizing extraction efficiency of active constituents from jakyakgamcho decoction, the complex formula of herbal medicines, paeoniae radix and glycyrrhizae radix. J Ethnopharmacol. 2007 ; 113(2) : 306-11. https://doi.org/10.1016/j.jep.2007.06.013
  18. M. K. Rafiq, E. Lee, M. Bradburnb. et al. Creatine kinase enzyme level correlates positively with serum creatinine and lean body mass, and is a prognostic factor for survival in amyotrophic lateral sclerosis. Eur J Neurol. 2016 ; 23(6) : 1071-8. https://doi.org/10.1111/ene.12995
  19. Cedarbaum JM, Stambler N, Malta E et al. The ALSFRS-R : a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci. 1999 ; 169(1-2) : 13-21. https://doi.org/10.1016/S0022-510X(99)00210-5
  20. Kim SC, Na WM, Lim NR et al. A pilot clinical study on the Traditional Korean Medicine treatment of Amyotrophic lateral sclerosis. J pharmacopuncture. 2009 ; 12(1) : 59.

Cited by

  1. Traditional East Asian Herbal Medicine for Amyotrophic Lateral Sclerosis: A Scoping Review vol.2021, pp.None, 2016, https://doi.org/10.1155/2021/5674142