생체재료학회지 (Biomaterials Research)

  • 제20권4호
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  • Pages.256-267
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  • 2016
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  • 1226-4601(pISSN)
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  • 2055-7124(eISSN)
한국생체재료학회 (Korean Society for Biomaterials)
권호 표지
DOI QR코드

DOI QR Code

Direct reprogramming and biomaterials for controlling cell fate

  • Kim, Eunsol (School of Materials Science and Engineering, Gwangju Institute of Science and Technology) ;
  • Tae, Giyoong (School of Materials Science and Engineering, Gwangju Institute of Science and Technology)
  • 투고 : 2016.10.01
  • 심사 : 2016.11.26
  • 발행 : 2016.12.01
⟨ 이전 논문 다음 논문 ⟩

초록

Direct reprogramming which changes the fate of matured cell is a very useful technique with a great interest recently. This approach can eliminate the drawbacks of direct usage of stem cells and allow the patient specific treatment in regenerative medicine. Overexpression of diverse factors such as general reprogramming factors or lineage specific transcription factors can change the fate of already differentiated cells. On the other hand, biomaterials can provide physical and topographical cues or biochemical cues on cells, which can dictate or significantly affect the differentiation of stem cells. The role of biomaterials on direct reprogramming has not been elucidated much, but will be potentially significant to improve the efficiency or specificity of direct reprogramming. In this review, the strategies for general direct reprogramming and biomaterials-guided stem cell differentiation are summarized with the addition of the up-to-date progress on biomaterials for direct reprogramming.

키워드

과제정보

연구 과제 주관 기관 : National Research Foundation of Korea (NRF)

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