생체재료학회지 (Biomaterials Research)

  • 제20권3호
  • /
  • Pages.191-199
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  • 2016
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  • 1226-4601(pISSN)
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  • 2055-7124(eISSN)
한국생체재료학회 (Korean Society for Biomaterials)
권호 표지
DOI QR코드

DOI QR Code

Collagen-grafted porous HDPE/PEAA scaffolds for bone reconstruction

  • Kim, Chang-Shik (Department of Polymer Science and Engineering, Kyungpook National University) ;
  • Jung, Kyung-Hye (Department of Advanced Materials and Chemical Engineering, Catholic University of Daegu) ;
  • Kim, Hun (Jeil Medical Corporation) ;
  • Kim, Chan-Bong (Jeil Medical Corporation) ;
  • Kang, Inn-Kyu (Department of Polymer Science and Engineering, Kyungpook National University)
  • 투고 : 2016.04.29
  • 심사 : 2016.07.19
  • 발행 : 2016.09.01
⟨ 이전 논문 다음 논문 ⟩

초록

After tumor resection, bone reconstruction such as skull base reconstruction using interconnected porous structure is absolutely necessary. In this study, porous scaffolds for bone reconstruction were prepared using heat-pressing and salt-leaching methods. High-density polyethylene (HDPE) and poly(ethylene-co-acrylic acid) (PEAA) were chosen as the polymer composites for producing a porous scaffold of high mechanical strength and having high reactivity with biomaterials such as collagen, respectively. The porous structure was observed through surface images, and its intrusion volume and porosity were measured. Owing to the carboxylic acids on PEAA, collagen was successfully grafted onto the porous HDPE/PEAA scaffold, which was confirmed by FT-IR spectroscopy and electron spectroscopy for chemical analysis. Osteoblasts were cultured on the collagen-grafted porous scaffold, and their adhesion, proliferation, and differentiation were investigated. The high viability and growth of the osteoblasts suggest that the collagen-grafted porous HDPE/PEAA is a promising scaffold material for bone generation.

키워드

과제정보

연구 과제 주관 기관 : Kyungpook National University

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  3. Effect of TiO2 Nanofiller Concentration on the Mechanical, Thermal and Biological Properties of HDPE/TiO2 Nanocomposites vol.27, pp.5, 2018, https://doi.org/10.1007/s11665-018-3305-y
  4. Effects of preparation processes on the structure and properties of collagen gel vol.36, pp.9, 2018, https://doi.org/10.1080/07373937.2017.1368542
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