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Electrophoretically prepared hybrid materials for biopolymer hydrogel and layered ceramic nanoparticles

  • Gwak, Gyeong-Hyeon (Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University) ;
  • Choi, Ae-Jin (Postharvest Research Team, National Institute of Horticultural and Herbal Science (NIHHS) of RDA) ;
  • Bae, Yeoung-Seuk (Postharvest Research Team, National Institute of Horticultural and Herbal Science (NIHHS) of RDA) ;
  • Choi, Hyun-Jin (Postharvest Research Team, National Institute of Horticultural and Herbal Science (NIHHS) of RDA) ;
  • Oh, Jae-Min (Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University)
  • Received : 2015.09.09
  • Accepted : 2016.01.04
  • Published : 2016.03.01

Abstract

Background: In order to obtain biomaterials with controllable physicochemical properties, hybrid biomaterials composed of biocompatible biopolymers and ceramic nanoparticles have attracted interests. In this study, we prepared biopolymer/ceramic hybrids consisting of various natural biopolymers and layered double hydroxide (LDH) ceramic nanoparticles via an electrophoretic method. We studied the structures and controlled-release properties of these materials. Results and discussion: X-ray diffraction (XRD) patterns and X-ray absorption spectra (XAS) showed that LDH nanoparticles were formed in a biopolymer hydrogel through electrophoretic reaction. Scanning electron microscopic (SEM) images showed that the ceramic nanoparticles were homogeneously distributed throughout the hydrogel matrix. An antioxidant agent (i.e., ferulic acid) was loaded onto agarose/LDH and gelatin/LDH hybrids, and the time-dependent release of ferulic acid was investigated via high-performance liquid chromatography (HPLC) for kinetic model fitting. Conclusions: Biopolymer/LDH hybrid materials that were prepared by electrophoretic method created a homogeneous composite of two components and possessed controllable drug release properties according to the type of biopolymer.

Keywords

Acknowledgement

Supported by : RDA

References

  1. Tathe A, Ghodke M, Nikalje AP. A brief review: biomaterials and their application. Int J Pharm Pharm Sci. 2010;2:19-23.
  2. Patel NR, Gohil PP. A review on biomaterials: scope, applications & human anatomy significance. Int J Emerging Technol Adv Eng. 2012;2:91-101.
  3. Lee HB. Needs and opportunities for the biomaterials industry. Polym Sci Technol. 1994;5:566-76.
  4. Griffith L. Polymeric biomaterials. Acta Mater. 2000;48:263-77. https://doi.org/10.1016/S1359-6454(99)00299-2
  5. Petzetakis N, Dove AP, O'Reilly RK. Cylindrical micelles from the living crystallization-driven self-assembly of poly (lactide)-containing block copolymers. Chem Sci. 2011;2:955-60. https://doi.org/10.1039/C0SC00596G
  6. Hayashi T. Biodegradable polymers for biomedical uses. Prog Polym Sci. 1994;19:663-702. https://doi.org/10.1016/0079-6700(94)90030-2
  7. Phadke A, Zhang C, Hwang Y, Vecchio K, Varghese S. Templated mineralization of synthetic hydrogels for bone-like composite materials: Role of matrix hydrophobicity. Biomacromolecules. 2010;11:2060-8. https://doi.org/10.1021/bm100425p
  8. Shih Y-RV, Hwang Y, Phadke A, Kang H, Hwang NS, Caro EJ, et al. Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. Proc Natl Acad Sci. 2014;111:990-5. https://doi.org/10.1073/pnas.1321717111
  9. Holmes RE. Bone regeneration within a coralline hydroxyapatite implant. Plast Reconstr Surg. 1979;63:626-33. https://doi.org/10.1097/00006534-197905000-00004
  10. Staiger MP, Pietak AM, Huadmai J, Dias G. Magnesium and its alloys as orthopedic biomaterials: a review. Biomaterials. 2006;27:1728-34. https://doi.org/10.1016/j.biomaterials.2005.10.003
  11. Narayan R. Biomedical materials, Springer Science & Business Media. 2009. pp. 41-81.
  12. Choi YS, Lee S, Hong SR, Lee Y, Song K, Park M. Studies on gelatin-based sponges. Part III: a comparative study of cross-linked gelatin/alginate, gelatin/hyaluronate and chitosan/hyaluronate sponges and their application as a wound dressing in full-thickness skin defect of rat. J Mater Sci Mater Med. 2001;12:67-73. https://doi.org/10.1023/A:1026765321117
  13. Cao Z, Gilbert RJ, He W. Simple Agarose-Chitosan Gel Composite System for Enhanced Neuronal Growth in Three Dimensions. Biomacromolecules. 2009;10:2954-9. https://doi.org/10.1021/bm900670n
  14. Du C, Cui F, Feng Q, Zhu X, de Groot K. Tissue response to nanohydroxyapatite/collagen composite implants in marrow cavity. J Biomed Mater Res. 1998;42:540-8. https://doi.org/10.1002/(SICI)1097-4636(19981215)42:4<540::AID-JBM9>3.0.CO;2-2
  15. Ito Y, Hasuda H, Kamitakahara M, Ohtsuki C, Tanihara M, Kang I-K, et al. A composite of hydroxyapatite with electrospun biodegradable nanofibers as a tissue engineering material. J Biosci Bioeng. 2005;100:43-9. https://doi.org/10.1263/jbb.100.43
  16. Gwak GH, Paek SM, Oh JM. Electrophoretic Preparation of an Organic-Inorganic Hybrid of Layered Metal Hydroxide and Hydrogel for a Potential Drug‐Delivery System. Eur J Inorg Chem. 2012;2012:5269-75. https://doi.org/10.1002/ejic.201200583
  17. Alaminos M, Sanchez-Quevedo MDC, Munoz-Avila JI, Serrano D, Medialdea S, Carreras I, et al. Construction of a complete rabbit cornea substitute using a fibrin-agarose scaffold. Invest Ophthalmol Vis Sci. 2006;47:3311-7. https://doi.org/10.1167/iovs.05-1647
  18. Mauck RL, Soltz MA, Wang CC, Wong DD, Chao P-HG, Valhmu WB, et al. Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J Biomech Eng. 2000;122:252-60. https://doi.org/10.1115/1.429656
  19. Campo VL, Kawano DF, da Silva DB, Carvalho I. Carrageenans: Biological properties, chemical modifications and structural analysis-A review. Carbohydr Polym. 2009;77:167-80. https://doi.org/10.1016/j.carbpol.2009.01.020
  20. Edwards C, Blackburn N, Craigen L, Davison P, Tomlin J, Sugden K, et al. Viscosity of food gums determined in vitro related to their hypoglycemic actions. Am J Clin Nutr. 1987;46:72-7. https://doi.org/10.1093/ajcn/46.1.72
  21. Wang L, Shelton R, Cooper P, Lawson M, Triffitt J, Barralet J. Evaluation of sodium alginate for bone marrow cell tissue engineering. Biomaterials. 2003;24:3475-81. https://doi.org/10.1016/S0142-9612(03)00167-4
  22. Tasneem M, Siddique F, Ahmad A, Farooq U. Stabilizers: Indispensable substances in dairy products of high rheology. Crit Rev Food Sci Nutr. 2014;54:869-79. https://doi.org/10.1080/10408398.2011.614702
  23. Oh EJ, Park K, Kim KS, Kim J, Yang J-A, Kong J-H, et al. Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives. J Control Release. 2010;141:2-12. https://doi.org/10.1016/j.jconrel.2009.09.010
  24. Cavani F, Trifiro F, Vaccari A. Hydrotalcite-type anionic clays: Preparation, properties and applications. Catal Today. 1991;11:173-301. https://doi.org/10.1016/0920-5861(91)80068-K
  25. Choy J-H, Jung J-S, Oh J-M, Park M, Jeong J, Kang Y-K, et al. Layered double hydroxide as an efficient drug reservoir for folate derivatives. Biomaterials. 2004;25:3059-64. https://doi.org/10.1016/j.biomaterials.2003.09.083
  26. Khan AI, Lei L, Norquist AJ, O'Hare D. Intercalation and controlled release of pharmaceutically active compounds from a layered double hydroxide. Chem Commun. 2001;2001:2342-3.
  27. Foord S, Atkins E. New x‐ray diffraction results from agarose: Extended single helix structures and implications for gelation mechanism. Biopolymers. 1989;28:1345-65. https://doi.org/10.1002/bip.360280802
  28. Ki CS, Baek DH, Gang KD, Lee KH, Um IC, Park YH. Characterization of gelatin nanofiber prepared from gelatin-formic acid solution. Polymer. 2005;46:5094-102. https://doi.org/10.1016/j.polymer.2005.04.040
  29. Woo MA, Song M-S, Kim TW, Kim IY, Ju J-Y, Lee YS, et al. Mixed valence Zn-Co-layered double hydroxides and their exfoliated nanosheets with electrode functionality. J Mater Chem. 2011;21:4286-92. https://doi.org/10.1039/c0jm03430d
  30. Hennig C, Hallmeier K-H, Zahn G, Tschwatschal F, Hennig H. Conformational influence of dithiocarbazinic acid bishydrazone ligands on the structure of zinc (II) complexes: a comparative XANES study. Inorg Chem. 1999;38:38-43. https://doi.org/10.1021/ic9804059
  31. Choy J-H, Kwon Y-M, Han K-S, Song S-W, Chang SH. Intra-and inter-layer structures of layered hydroxy double salts, $Ni_{1−x}Zn_{2x}(OH)_{2}(CH_{3}CO_{2})_{2x}{\cdot}nH_{2}O. Mater Lett. 1998;34:356-63. https://doi.org/10.1016/S0167-577X(97)00191-2
  32. Li Y, Rodrigues J, Tomas H. Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications. Chem Soc Rev. 2012;41:2193-221. https://doi.org/10.1039/C1CS15203C
  33. Oh J-M, Biswick TT, Choy J-H. Layered nanomaterials for green materials. J Mater Chem. 2009;19:2553-63. https://doi.org/10.1039/b819094a
  34. Lima E, Flores J, Cruz AS, Leyva-Gomez G, Krotzsch E. Controlled release of ferulic acid from a hybrid hydrotalcite and its application as an antioxidant for human fibroblasts. Microporous Mesoporous Mat. 2013;181:1-7. https://doi.org/10.1016/j.micromeso.2013.07.014
  35. Chein S, Clayton W. Application of Elovich equation to the kinetics of phosphate release and sorption in soil. J Am Soil Sci Soc. 1980;44:265-8. https://doi.org/10.2136/sssaj1980.03615995004400020013x
  36. Yang J-H, Han Y-S, Park M, Park T, Hwang S-J, Choy J-H. New inorganicbased drug delivery system of indole-3-acetic acid-layered metal hydroxide nanohybrids with controlled release rate. Chem Mater. 2007;19:2679-85. https://doi.org/10.1021/cm070259h

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