Comparison of Conventional and Hypofractionated Radiotherapy in Breast Cancer Patients in Terms of 5-Year Survival, Locoregional Recurrence, Late Skin Complications and Cosmetic Results

  • Hashemi, Farnaz Amouzegar (Radiation Oncology Research Center, Tehran University of Medical Sciences) ;
  • Barzegartahamtan, Mohammadreza (Mofatteh Hospital, Shahid Beheshti University of Medical Sciences) ;
  • Mohammadpour, Reza Ali (Department of Biostatistics, Health Sciences Research Center, Mazandaran University of Medical Sciences) ;
  • Sebzari, Ahmadreza (Department of Radiation Oncology, Valiasr Hospiatl, Birjand University of Medical Sciences) ;
  • Kalaghchi, Bita (Radiation Oncology Research Center, Tehran University of Medical Sciences) ;
  • Haddad, Peiman (Radiation Oncology Research Center, Tehran University of Medical Sciences)
  • Published : 2016.11.01


Bckground: Adjuvant radiation therapy is commonly administered following breast-conserving surgery for breast cancer patients. Hypofractionated radiotherapy can significantly reduce the waiting time for radiotherapy, working load on machines, patient visits to radiotherapy departments and medical costs. Material/Methods: Fifty-two patients with operable breast cancer (pT1-3pN0M0) who underwent breast conservation surgery in Tehran Cancer Institute during January 2011 to January 2012, were randomly assigned to undergo radiotherapy in two arms (hypofractionated radiotherapy arm with 30 patients, dose 42.5 Gy in 16 fractions; and conventional radiotherapy arm with 22 patients, dose 50 Gy in 25 fractions). W compared these two groups in terms of overall survival, locoregional control, late skin complications and cosmetic results. Results: At a median follow-up of 52.4 months (range: 0-64 months), the follow-up rate was 82.6%. Overall, after 60 months, there was no detectable significant differences between groups regarding cosmetic results (p = 0.857), locoregional control or survival. Conclusions: The results confirm that hypofractionated radiotherapy with a subsequent boost is as effective as conventional radiotherapy, is well-tolerated and can be used as an alternative treatment method following breast conservation surgery.


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