Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Lack of Evidence for a Relationship between High Risk Human Papillomaviruses and Breast Cancer in Iranian Patients

  • Doosti, Masoud (Department of Animal Viral Disease Research and Diagnosis, Razi Vaccine & Serum Research Institute) ;
  • Bakhshesh, Mehran (Department of Animal Viral Disease Research and Diagnosis, Razi Vaccine & Serum Research Institute) ;
  • Zahir, Shokouh Taghipour (Clinical and Surgical Pathology, Shahid Sadooghi University of Medical Science) ;
  • Shayestehpour, Mohammad (Department of Virology, School of Public Health, Tehran University of Medical Sciences) ;
  • Karimi-Zarchi, Mojgan (Department of Obstetrics and Gynecology, Shahid Sadooghi University of Medical Science)
  • Published : 2016.09.01
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Abstract

Background: Whether there is any relationship between human papilloma virus (HPV) and breast carcinoma is not clear. Some previous studies have indicated a possible role in oncogenesis in the breast. In this study, we therefore analyzed the presence of HPV infection in breast tissues of Iranian women from Yazd city. Materials and Methods: In a cross-sectional study, formalin-fixed paraffin-embedded tissues from 87 patients with breast cancer and 84 cases with breast fibrocystic lesions (control group) were selected from a tissue archive. Grade of tumors and fibrocystic tissues were determined by two pathologists. The nested-PCR method was performed for detection of HPVs in samples. HPV genotypes were determined by sequencing and the phylogenetic tree depicted by MEGA software. Results: Of the 87 women with breast cancer, 22.9% (20 isolates) had positive results for HPV DNA. In the control group no HPV was detected. The HPV genotypes in positive samples were HPV-16 (35%) HPV-18 (15%), HPV-6 (45%) and HPV-11 (5%). The data did not approved a significant correlation between tissue pathology of breast cancer and the HPV genotype frequency. Conclusions: The data did not provide any evidence for a role of high risk HPV types in oncogenesis in the breast.

Keywords

References

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