Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지

Potential Risk Factors for Breast Cancer in Pakistani Women

  • Bano, Raisa (Department of Bioinformatics and Biosciences, Capital University of Science and Technology) ;
  • Ismail, Muhammad (Institute of Biomedical and Genetic Engineering) ;
  • Nadeem, Aamer (Department of Bioinformatics and Biosciences, Capital University of Science and Technology) ;
  • Khan, Mohammad Haroon (Department of Bioinformatics and Biosciences, Capital University of Science and Technology) ;
  • Rashid, Hamid (Department of Bioinformatics and Biosciences, Capital University of Science and Technology)
  • Published : 2016.09.01
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Abstract

Background: Breast cancer is the most common female malignancy worldwide and its incidence is on the rise in Pakistan. The aim of this case-control study was to quantify the association of various risk factors with breast cancer risk among Pakistani women. Materials and Methods: A total of 2,246 women were studied, including 1,238 women with histologically confirmed breast cancer patients and age matched control subjects (N=1008) without breast cancer and other chronic diseases. Subjects were interviewed using a specifically designed questionnaire. Unconditional logistic regression was applied. Subsequent disease-specific mortality was also measured. Results: In this study, majority of the breast cancer patients (69.59%) were in age ranges of 40s and 50s. BMI greater than 25kg/m2 (OR=1.57; 95%CI, 1.26-1.90 and OR=1.60; 95%CI, 1.26-2.03), marital status of unmarried (OR=2.03; 95%CI, 1.69-2.44), lack of breast feeding, smoking (current or ever), lack of physical activity and post-menopausal status were found to have significant positive associations with breast cancer. It was also observed that increased parity reduced the disease risk. A larger number of cases (58.1%) had their right breast affected while 22.8% had other complications as well. Conclusions: This exploratory analysis indicated a number of risk factors to be associated with increased risk of breast cancer. It was also observed that mean age at diagnosis is a decade earlier than in western countries. It is hoped that our findings will facilitate establishment of adequate evidence-based awareness and preventive measures for Pakistani women.

Keywords

References

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