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Association between Pesticide Use and Cholangiocarcinoma

  • Jeephet, Kornthip (Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University) ;
  • Kamsa-ard, Siriporn (Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University) ;
  • Bhudhisawasdi, Vajarabhongsa (Department of Surgery, Faculty of Medicine, Khon Kaen University) ;
  • Kamsa-ard, Supot (Cancer Unit, Faculty of Medicine, Khon Kaen University) ;
  • Luvira, Varisara (Department of Community Medicine, Faculty of Medicine, Khon Kaen University) ;
  • Luvira, Vor (Department of Surgery, Faculty of Medicine, Khon Kaen University)
  • Published : 2016.08.01

Abstract

Background: Thailand remains a primarily agricultural country and Thai farmers are heavy users of pesticides. Coincidentally the incidence of cholangio carcinoma (CCA) is high in parts of the country, but no previous study has examined any association between the two. Materials and Methods: The present matched, case-control study covered patients admitted to Srinagarind Hospital, Khon Kaen University, Thailand. The case group comprised 210 cases diagnosed with CCA and the control group 840 diagnosed with other diseases. Cases and controls were matched for sex, age within five years, and date of admission within three months. Multiple conditional logistic regression was used for the analysis. Results: After adjusting for potential confounders, pesticide use as compared with never used pesticide was not associated with CCA (ORadj=1.11, 95% CI: 0.77, 1.60) and neither was there any significant relationship between CCA and duration of pesticide use, type or number of types pesticide use. Conclusions: The current study thus found no association between pesticide use and CCA.

Keywords

Acknowledgement

Supported by : Khon Kaen University

References

  1. Acquavella J, Doe J, Tomenson J, et al (2003). Epidemiologic studies of occupational pesticide exposure and cancer: Regulatory risk assessments and biologic plausibility. Ann Epidemiol, 13, 1-7.
  2. Alavanja MCR, Bonner MR (2012). Occupational pesticide exposures and cancer risk: a review. J Toxicol Environmental Health, 15, 238-63. https://doi.org/10.1080/10937404.2012.632358
  3. American Cancer Society (2014). Bile Duct Cancer (Cholangiocarcinoma). Available at http://www.cancer.org/acs/groups/cid/documents/ webcontent/003084-pdf. Accessed: March 2015.
  4. Available at http://serc.carleton.edu/NAGTWorkshops/health case_studies/pesticides.html. Accessed: September 2015.
  5. Bragazzi MC, Cardinale V, Carpino G, et al (2011). Cholangiocarcinoma: Epidemiology and risk factors. Translational Gastrointestinal Cancer, 1, 21-32.
  6. Bridget Hicks National Association of Geoscience Teachers (NAGT) Agricultural Pesticides and Human Health (2013).
  7. Darwin PE, Harris JE, Kennedy AS, et al (2015). Cholangiocarcinoma. Available at http://emedicine.medscape.com/article/277393-overview. Accessed: March 2015.
  8. International Agency for Research on Cancer (2015). GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. Available at http://globocan.iarc.fr/Pages/fact_sheets_population.aspx/. Accessed: February 2015.
  9. Kamsa-Ard S, Luvira V, Pugkhem A, et al (2015). Association between praziquantel treatment and cholangiocarcinoma: a hospital-based matched case-control study. BMC Cancer, 15, 776. https://doi.org/10.1186/s12885-015-1788-6
  10. Kearns J (2008). Pesticide use in Thailand and the United States: Ecological and Human Health Effects. Available at http://www.aqsolutions.org/images/2008/04/pesticide-use-inthailand- and-the-us.pdf. Accessed: September 2015.
  11. Michigan Department of Community Health (2004). What You Need to Know About Pesticides and Your Health. Available at https://www.michigan.gov/documents/mdch_Pesticide_ Booklet_97200_7.pdf. Accessed: March 2015.
  12. National Statistical Office, Ministry of Information and Communication Technology (2014). Agricultural Census, Whole Kingdom. Available at http://web.nso.go.th/en/ census/agricult/cen_agri03.htm. Accessed: September 2015.
  13. Pairojkul C, Shirai T, Hirohashi S, et al (1991). Multistage carcinogenesis of liver-fluke-associated cholangiocarcinoma in Thailand. Princess Takamatsu Symposia, 22, 77-86.
  14. Panuwet P, Siriwong W, Prapamontol T, et al (2012). Agricultural pesticide management in Thailand: Situation and population health risk. Env Science Policy, 17, 72-81. https://doi.org/10.1016/j.envsci.2011.12.005
  15. Parron T, Requena M, Hernandez AF, et al (2014). Environmental exposure to pesticides and cancer risk in multiple human organ systems. Toxicology Letters, 230, 157-65. https://doi.org/10.1016/j.toxlet.2013.11.009
  16. Sripa B, Kaewkes S, Sithithaworn P, et al (2007). Liver fluke induces cholangiocarcinoma. PLoS Medicine, 4, 201. https://doi.org/10.1371/journal.pmed.0040201
  17. Schmeisser N, Kaerlev L, Bourdon-Raverdy N, et al (2010). Occupational exposure to pesticides and bile tract carcinoma in men: results from a European multicenter case-control study. Cancer Causes Control, 21, 1493-502. https://doi.org/10.1007/s10552-010-9578-6
  18. Tawatsin A, Thavara U, Siriyasatien P (2015). Pesticides used in Thailand and toxic effects to human health. Medical Research Archives, 1-10.
  19. Thai Organic Trade Association. Overview of Organic Agriculture in Thailand (2011). Available at http://www.thaiorganictrade.com/en/article/442. Accessed: September 2015.
  20. Watanapa P, Watanapa WB (2002). Liver fluke-associated cholangiocarcinoma. Br J Surg, 89, 962-70. https://doi.org/10.1046/j.1365-2168.2002.02143.x
  21. Wiwanitkit V (2009). Pesticides, fresh water fish, liver flukes and nitrosamines: A story of cholangiocarcinoma development in Thailand. Asian Pac J Cancer Prev, 10, 939-40.