Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Prevalence and Associated Factors of Abnormal Cervical Cytology and High-Risk HPV DNA among Bangkok Metropolitan Women

  • Tangjitgamol, Siriwan (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) ;
  • Kantathavorn, Nuttavut (Section of Obstetrics and Gynecology, Chulabhorn Hospital) ;
  • Kittisiam, Thannaporn (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) ;
  • Chaowawanit, Woraphot (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) ;
  • Phoolcharoen, Natacha (Section of Obstetrics and Gynecology, Chulabhorn Hospital) ;
  • Manusirivithaya, Sumonmal (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) ;
  • Khunnarong, Jakkapan (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) ;
  • Srijaipracharoen, Sunamchok (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) ;
  • Saeloo, Siriporn (Data Management Unit, Chulabhorn Hospital) ;
  • Krongthong, Waraporn (Data Management Unit, Chulabhorn Hospital) ;
  • Supawattanabodee, Busaba (Research Facilitation Unit, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) ;
  • Thavaramara, Thaovalai (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University) ;
  • Pataradool, Kamol (Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University)
  • Published : 2016.07.01
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Abstract

Background: Many strategies are required for cervical cancer reduction e.g. provision of education cautious sexual behavior, HPV vaccination, and early detection of pre-invasive cervical lesions and invasive cancer. Basic health data for cervical cytology/ HPV DNA and associated factors are important to make an appropriate policy to fight against cervical cancer. Aims: To assess the prevalence of abnormal cervical cytology and/or HPV DNA and associated factors, including sexual behavior, among Bangkok Metropolitan women. Materials and Methods: Thai women, aged 25-to-65 years old, had lived in Bangkok for ${\geq}5$ years were invited into the study. Liquid-based cervical cytology and HPV DNA tests were performed. Personal data were collected. Main Outcomes Measures: Rates of abnormal cytology and/ or high-risk HPV (HR-HPV) and factors associated with abnormal test (s) were studied. Results: Abnormal cytology and positive HR-HPV were found in 6.3% (279/4442 women) and 6.7% (295/4428), respectively. The most common abnormal cytology was ASC-US (3.5%) while the most common HR-HPV genotype was HPV 16 (1.4%) followed by HPV 52 (1.0%), HPV 58 (0.9%), and HPV 18 and HPV 51 at equal frequency (0.7%). Both tests were abnormal in 1.6% (71/4428 women). Rates of HR-HPV detection were directly associated with severity of abnormal cytology: 5.4% among normal cytology and 13.0%, 30.8%, 40.0%, 39.5%, 56.3% and 100.0% among ASC-US, ASC-H, AGC-NOS, LSIL, HSIL, and SCC, respectively. Some 5% of women who had no HR-HPV had abnormal cytology, in which 0.3% had ${\geq}$ HSIL. Factors associated with abnormal cytology or HR-HPV were: age ${\leq}40$ years, education lower than (for cytology) or higher than bachelor for HR-HPV), history of sexual intercourse, and sexual partners ${\geq}2$. Conclusions: Rates for abnormal cytology and HR-HPV detection were 6.3% and 6.7% HR-HPV detection was directly associated with severity of abnormal cytology. Significant associated factors were age ${\leq}40$ years, lower education, history of sexual intercourse, and sexual partners ${\geq}2$.

Keywords

References

  1. Arbyn M, Benoy I, Simoens C, et al (2009). Prevaccination distribution of human papillomavirus types in women attending at cervical cancer screening in Belgium. Cancer Epidemiol Biomarkers Prev, 18, 321-30. https://doi.org/10.1158/1055-9965.EPI-08-0510
  2. Bureau of Policy and Strategy. Ministry of public health Thailand. Available at http://ghdx.healthdata.org/record/thailand-public-health-statistics-2009. Accessed on October 10, 2015.
  3. Bruni L, Diaz M, Castellsague X, et al (2010). Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings. J Infect Dis, 202, 1789-99. https://doi.org/10.1086/657321
  4. Chandeying V, Garland SM, Tabrizi SN (2006). Prevalence and typing of human papillomavirus (HPV) among female sex workers and outpatient women in southern Thailand. Sex Health, 3, 11-4. https://doi.org/10.1071/SH05019
  5. Chansaenroj J, Lurchachaiwong W, Termrungruanglert W, et al (2010). Prevalence and genotypes of human papillomavirus among Thai women. Asian Pac J Cancer Prev, 11, 117-22.
  6. Chomsevi K, Jatuparisuth N(2002). Abnormal Pap smear of the uterine cervix at BMA general hospital. Vajira Med J, 46, 97-104.
  7. Cuzick J, Szarewski A, Cubie H, et al (2003). Management of women who test positive for high-risk types of human papillomavirus: the HART study. Lancet, 362, 1871-6. https://doi.org/10.1016/S0140-6736(03)14955-0
  8. de Sanjose S, Diaz M, Castellsague X, et al (2007). Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis, 7, 453-9. https://doi.org/10.1016/S1473-3099(07)70158-5
  9. Ferreccio C, Barriga MI, Lagos M, et al (2013). Screening trial of human papillomavirus for early detection of cervical cancer in Santiago, Chile. Int J Cancer, 132, 916-23. https://doi.org/10.1002/ijc.27662
  10. Franceschi S, Herrero R, Clifford GM, et al (2006). Variations in the age-specific curves of human papillomavirus prevalence in women worldwide. Int J Cancer, 119, 2677-84. https://doi.org/10.1002/ijc.22241
  11. Insinga RP, Glass AG, Rush BB (2004). Diagnoses and outcomes in cervical cancer screening: A population-based study. Am J Obstet Gynecol, 191, 105-13. https://doi.org/10.1016/j.ajog.2004.01.043
  12. International Agency for Research on Cancer. Population fact sheets. Available at http://globocan.iarc.fr/Pages/fact_sheets_population.aspx (2012). Accessed on October 18, 2015.
  13. Kantathavorn N, Mahidol C, Sritana N, et al (2015). Genotypic distribution of human papillomavirus (HPV) and cervical cytology findings in 5906 Thai women undergoing cervical cancer screening programs. Infect Agent Cancer, 10, 7. https://doi.org/10.1186/s13027-015-0001-5
  14. Leinonen M, Kotaniemi-Talonen L, Anttila A, et al (2008). Prevalence of oncogenic human papilloma virus infection in an organised screening population in Finland. Int J Cancer, 123, 1344-9. https://doi.org/10.1002/ijc.23670
  15. Li J, Huang R, Schmidt JE, Qiao YL (2013). Epidemiological features of human papillomavirus (HPV) infection among women living in mainland China. Asian Pac J Cancer Prev, 14, 4015-23. https://doi.org/10.7314/APJCP.2013.14.7.4015
  16. Moore MA, Attasara P, Khuhaprema T, et.al (2010). Cancer epidemiology in mainland South-East Asia - past, present and future. Asian Pac J Cancer Prev, 11, 67-80.
  17. Munoz N, Hernandez-Suarez G, Mendez F, et al (2009). Persistence of HPV infection and risk of high-grade cervical intraepithelial neoplasia in a cohort of Colombian women. Br J Cancer, 100, 1184-90. https://doi.org/10.1038/sj.bjc.6604972
  18. Parkin DM, Louie KS, Clifford G (2008). Burden and trends of type-specific human papillomavirus infections and related diseases in the Asia Pacific region. Vaccine, 26, 1-16.
  19. Rugpao S, Koonlertkit S, Ruengkrist T, et al (2009). ThinPrep Pap-smear and cervical intraepithelial neoplasia in reproductive-aged Thai women. J Obstet Gynaecol Res, 35, 551-4. https://doi.org/10.1111/j.1447-0756.2008.00566.x
  20. Siriaunkgul S, Settakorn J, Sukpan K, et al (2014). Populationbased cervical cancer screening using high-risk HPV DNA test and liquid-based cytology in northern Thailand. Asian Pac J Cancer Prev, 15, 6837-42. https://doi.org/10.7314/APJCP.2014.15.16.6837
  21. Sukvirach S, Smith JS, Tunsakul S, et al (2003). Populationbased human papillomavirus prevalence in Lampang and Songkla, Thailand. J Infect Dis, 187, 1246-56. https://doi.org/10.1086/373901
  22. Swangvaree SS, Kongkaew P, Rugsuj P, Saruk O (2010). Prevalence of high-risk human papillomavirus infection and cytologic results in Thailand. Asian Pac J Cancer Prev, 11, 1465-8.
  23. Wright TC Jr, Massad LS, Dunton CJ, et al (2007). 2006 consensus guidelines for the management of women with abnormal cervical screening tests. J Low Genit Tract Dis, 11, 201-22. https://doi.org/10.1097/LGT.0b013e3181585870
  24. Zhao FH, Zhu FC, Chen W, et al (2014). HPV-039 study group: Baseline prevalence and type distribution of human papillomavirus in healthy 20 Chinese women aged 18-25 years enrolled in a clinical trial. Int J Cancer, 135, 2604-11. https://doi.org/10.1002/ijc.28896
  25. Zorzi M, Del Mistro A, Farruggio A, et al (2013). Use of a highrisk human papillomavirus DNA test as the primary test in a cervical cancer screening programme: a population-based cohort study. BJOG, 120, 1260-7. https://doi.org/10.1111/1471-0528.12272