Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Relapsed Wilms' tumor with multiple brain metastasis

  • Akakin, Akin (Department of Neurosurgery, Bahcesehir University Medical Faculty) ;
  • Yilmaz, Baran (Department of Neurosurgery, Bahcesehir University Medical Faculty) ;
  • Eksi, Murat Sakir (Department of Orthopedic Surgery-Spine Center, University of California at San Francisco) ;
  • Yapicier, Ozlem (Department of Pathology, Bahcesehir University Medical Faculty) ;
  • Kilic, Turker (Department of Neurosurgery, Bahcesehir University Medical Faculty)
  • Received : 2015.02.25
  • Accepted : 2015.11.26
  • Published : 2016.11.15
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Abstract

Wilms' tumor is the most common malignant renal tumor in childhood. The brain metastasis of a Wilms' tumor with anaplastic histopathology is rare. We present the case of an 8-year-old girl with Wilms' tumor, who presented with multiple brain metastases 5 years after her primary diagnosis. The brain masses were diagnosed after a generalized tonic-clonic seizure attack. The big solid mass in the cerebellum was resected, and whole-brain radiotherapy was performed, after which, she succumbed to her disease. In the case of clinical suspicion, cranial surveillance should be included in the routine clinical work-up for Wilms' tumor. Combined aggressive therapy (surgery+radiotherapy+chemotherapy) should be applied whenever possible, for both better survival and palliative aspects.

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References

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